Tyson McDonald, PhD. Postdoctoral Fellow Center of Cancer Systems Biology Caritas St.Elizabeth's Medical Center Tufts University School of Medicine 736 Cambridge Street Boston, MA 02135   Tel: 617.779.6534 Mail: tyson.mcdonald [at] caritaschristi.edu

Education and Training:
PhD in Biomedical Physics, University of California Los Angeles, Sept 2004 to June 2009
BS in Nuclear Engineering, University of Michigan Ann Arbor, Sept 1999 to June 2004

Research description:

The classic outcomes of radiation exposure like cell cycle arrest, apoptosis, and senescence may form barriers to the introduction of genomic instability and cancer but these are sometimes circumvented by cellular resistance mechanisms that may be up-regulated to enhance the probability of survival. Ionizing radiation is an exogenous stress that has powerful effects on cell death and multiple signaling pathways. The pathways that are activated within the signaling network therefore serve as targets for interventions aimed at controlling responses in potentially harmful environments. My research aims to better understand the delayed effects of ionizing radiation that increase neoplastic transformation and malignancy.