Shiva Kalinga, PhD.
 
Center of Cancer Systems Biology
Caritas St.Elizabeth's Medical Center
Tufts University School of Medicine
736 Cambridge Street
Boston, MA 02135
 
Tel: 617.779.6543
Mail: shiva.kalinga [at] caritaschristi.org

Education and Training:
Postdoctoral fellowship, Bioengineering, Massachusetts Institute of Technology
Ph.D., Biochemistry, Swiss Federal Institute of Technology
M.S., Microbiology, Bangalore University

Research Support:

  1. MIT-Merck Postdoctoral Training Grant, USA (2005-07): Genomic Approaches to Understanding Cellular Determinants of DNA Damage
  2. Swiss National Foundation for Scientific Research Scholarship, Switzerland (2000-2005): Post-translation Modifications of Hemeproteins
  3. Global COE Summer Research Grant, Japan (2004): Design and Construction of Artificial Functional Myoglobin

 
Selected publications:

  1. Herold S, Kalinga S, Matsui T, Watanabe Y. Mechanistic studies of the Isomerization of Peroxynitrite to Nitrate Catalyzed by Distal Histidine Metmyoglobin Mutants. J Am Chem Soc 2004; 126: 6945
  2. Herold S, Kalinga S. Hemoglobin and Methemoglobin catalyze the Isomerization of Peroxynitrite to Nitrate. Biochemistry 2003; 42: 14036
  3. Herold S, Kalinga S, Mehl M. Myoglobin Scavenges Peroxynitrite without being Significantly Nitrated. Biochemistry 2002; 41: 13460
  4. Kalinga S, Subbayya IN, Balaram H. Development of a Bacterial Screen for Novel Hypoxanthine-guanine phosphoribosyltransferase Substrates. J Mol Microbiol Biotechnol 2001; 3: 557
  5. Subbayya IN, Sukumaran S, Kalinga S, Balaram H. Unusual Substrate Specificity of a Chimeric Hypoxanthine-guanine phosphoribosyltransferase Containing Segments from the Plasmodium falciparum and Human Enzymes. Biochem Biophys Res Comm 2000; 272: 596

Book chapters/Invited reviews:

  1. Dedon PC, Barth M, Chen B, DeMott M, Dendroulakis V, Dong M, Kalinga S, Elmquist E, Margolin Y, Pang B, Zhou X. Diverse Mechanisms of Endogenous Nucleobase Deamination in DNA and RNA. Advances in Molecular Toxicology 2006 ed J Fishbein, Elsevier; Amsterdam pp 25
  2. Kalinga S. Interaction of Peroxynitrite with Myoglobin and Hemoglobin. Can J Chem 2006; 84: 788