Nava Almog, PhD. Center of Cancer Systems Biology Caritas St.Elizabeth's Medical Center Tufts University School of Medicine 736 Cambridge Street Boston, MA 02135   Tel: 617.779.6532 Mail: nava.almog [at] tufts.edu

Education and Training:
Post-doctoral training, in the laboratory of Dr. Judah Folkman, Vascular Biology Program, Surgical Research Department, Children's Hospital, Harvard Medical School, Boston, MA, USA. 2001-2006
PhD, Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Analyzed the regulation of p53 tumor suppressor protein activity by it's C' terminus. Supervisor: Dr. Varda Rotter. 1995-2000
MSc, Department of Microbiology, Hebrew university, Jerusalem, Israel. Cum Laude. Investigated the mechanisms of control of the HIV-1 protease by the p6 protein. Supervisor: Dr. Moshe Kotler. 1991-1994
BSc, Faculty of Life Science, Hebrew university, Jerusalem, Israel. Cum Laude. 1988-1991

Research interests:

I am interested in the molecular mechanisms that underlie dormancy of human tumors. I previously established experimental models of human tumor dormancy in animals, isolated several human tumor cell lines that generate microscopic and non-angiogenic tumors and investigated their molecular characteristics in-vitro and the correlation to tumor growth patterns in-vivo. Currently employing a whole genome expression profiles analysis to characterize common molecular pathways in dormant tumors.

 
Recent publications:

Almog, N., Ma, L., Raychowdhury, R., Schwager, C., Erber, R., Short, S., Hlatky, L., Vajkoczy, P., Huber, P.E., Folkman, J., Abdollahi, A., (2009) Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype Cancer Res 69(3) 836-844.

Almog, N., Li, R., Peled, A., Schwartz, D., Wolkowicz, R., Goldfinger, N., Pei, H., Rotter, V., (1997) The C'-terminally alternatively spliced form of p53 induces attenuated apoptosis in myeloid cells, Mol. Cell Biol. 17 (2) 713-22.

Almog, N., Rotter, V., (1997) Involvement of p53 in cell differentiation and development, Biochim. Biophys. Acta. 1333 (1) F1-27.

Almog, N., Rotter, V., (1998) An insight into the life of p53: a protein coping with many functions, Biochim. Biophys. Acta. 1378 (3) R43-R54

Almog, N., Goldfinger, N., Rotter, V., (2000) p53 dependent apoptosis is regulated by a C-terminally alternatively spliced form of murine p53, Oncogene, 19, 3395-3403.

Almog, N., Milyavsky, M., Stabolsky P., Falcovitz, A., Goldfinger, N., Rotter, V., (2001) The role of the C' terminus of murine p53 in the p53/mdm-2 regulatory loop. Carcinogenesis 22 (5) 779-85.

N Almog, V Henke, L Flores, L Hlatky, AL Kung, R Wright, R Berger, L Hutchinson, E-G Achilles, J Folkman., (2006) Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis. FASEB J. 20(7):947-9.

Naumov, G. N., Sampson, D. A., Bender, E. R., Zurakowski, D., Flynn, E., Klement, G., Soo-Young Kang., Randolph Watnick., Folkman, J., and Almog, N., (2006). A model of human tumor dormancy: Spontaneous switch to the angiogenic phenotype via PI3K/c-myc-mediated repression of Thrombospondin-1. J Natl Cancer Inst;98(5):316-25.