Publications

This is a list of recent representative publications from the group or group members of the CCSB.

   jump to year  2012, 2011, 2010, 2009, 2008, 2007.

2012

• Isolation and Proteomic Analysis of Platelets by SELDI-TOF MS.
  Downing SR, Klement, GL. Methods Mol Biol. 2012;818:153-70. [Abstract]
  
  

2011

• Double-strand break motions shift radiation risk notions?
  Hlatky, L. Proc Natl Acad Sci U S A. 2011 Dec 30. [Epub ahead of print]  [Abstract]
  
  
• Non-Stem Cancer Cell Kinetics Modulate Solid Tumor Progression.
  Morton CI, Hlatky, L, Hahnfeldt P, Enderling, H. Theor Biol Med Model. 2011 Dec 30; 8(1)48. [Abstract]
  
  
• Breaking the 'harmony' of TNF-α signaling for cancer treatment.
  Sasi SP, Yan X, Enderling H, Park D, Gilbert HY, Curry C, Coleman C, Hlatky L, Qin G, Kishore R, Goukassian DA. Oncogene. 2011 Dec 12. doi: 10.1038/onc.2011.567. [Epub 2011 Dec 12.] [Abstract]
  
  
• Intercellular Communication by Exchange of Cytoplasmic Material via Tunneling Nano-Tube Like Structures in Primary Human Renal Epithelial Cells.
  Domhan S, Ma L, Tai A, Anaya Z, Beheshti Z, Zeier M, Hlatky L, Abdollahi A. PLos One 6(6):e21283, 2011. Epub 2011 Jun 27. [Abstract]
  
  
• Review and application of group theory to molecular systems biology.
  Rietman EA, Karp RL, Tuszynski JA. Theor Biol Med Model 8:21, 2011. [Abstract]
  
  
• Interactomes, manufacturomes and relational biology: analogies between systems biology and manufacturing systems.
  Rietman EA, Colt JZ, Tuszynski JA. Theor Biol Med Model 8:19, 2011. [Abstract]
  
  
• Low-Dose Radiation Knowledge Worth the Cost.
  Barcellos-Hoff MH, Brenner DJ, Brooks AL, Formenti S, Hlatky L, Locke PA, Shore R, Tenforde T, Travis El, Williams J. Science 332(6027):305-306, 2011. [Abstract]
  
  
• Cancer stem cells in solid tumors: is 'evading apoptosis' a hallmark of cancer?
  Enderling H, Hahnfeldt P. Prog Biophys Mol Biol 106:391-399, 2011. [Abstract]
  
  
• A multicellular basis for the origination of blast crisis in chronic myeloid leukemia.
  Sachs RK, Johnsson K, Hahnfeldt P, Luo J, Chen A, Hlatky L. Cancer Res 71(8):2838-2847, 2011. [Abstract]
  


• Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling.
  Tang J, Enderling H, Becker-Weimann S, Pham C, Polyzos A, Chen CY, Costes SV. Integr Biol 3(4):408-421, 2011. [Abstract]
  
  
• Two endogenous antiangiogenic inhibitors, endostatin and angiostatin, demonstrate biphasic curves in their antitumor profiles.
  Javaherian K, Lee TY, Tjin Tham Sjin RM, Parris GE, Hlatky L. Dose Response 9(3):369-376, 2011. [Abstract]
  
  
• A new view of radiation-induced cancer.
  Shuryak I, Sachs RK, Brenner DJ. Radiat Prot Dosimetry 143(2-4): 358-364, 2011. [Abstract]
  
  

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2010

• HSPG-binding peptide corresponding to the exon 6a-encoded domain of VEGF inhibits tumor growth by blocking angiogenesis in murine model.
  Lee TY, Folkman J, Javaherian K. PLoS One 5(4): e9945, 2010. [Abstract]
   
• Significance of tumor self-seeding as an augmentation to the classic metastasis paradigm.
  Hahnfeldt P. Future Oncol. 6(5): 681-685, 2010. [Abstract]
   
• Ionizing radiation activates the Nrf2 antioxidant response.
  McDonald JT, Kim K, Norris AJ, Vlashi E, Phillips TM, Lagadec C, Della Donna L, Ratikan J, Szelag H, Hlatky L, McBride WH. Cancer Res. 70(21): 8886-88953, 2010 [Abstract]
   
• The promoting role of a tumour-secreted chemorepellent in self-metastatic tumour progression.
  Enderling H, Hlatky L, Hahnfeldt P. Math Med Biol, 2010 [Abstract]
   
• Quantitative modeling of tumor dynamics and radiotherapy.
  Enderling H, Chaplain MAJ, Hahnfeldt P. Acta Biotheor 58(4): 341-353, 2010. [Abstract]
   
• Cancer risks after radiation exposure in middle age.
  Shuryak I, Sachs RK, Brenner DJ. J Natl Cancer Inst 102(21): 1628-1636, 2010. [Abstract]
  
  
• The balance between initiation and promotion in radiation-induced murine carcinogenesis.
  Shuryak I, Ullrich RL, Sachs RK, Brenner DJ. Radiat Res 174(3): 357-366, 2010. [Abstract]
  
  
• Whole blood transcriptomics in cardiac surgery identifies a gene regulatory network connecting ischemia reperfusion with systemic inflammation.
  Liangos O, Domhan S, Schwager C, Zeier M, Huber PE, Addabbo F, Goligorsky MS, Hlatky L, Jaber BL, Abdollahi A. PLoS One 5(10): e13658, 2010. [Abstract]
  
  
• Platelet Proteome and Tumor Dormancy: Can Platelets Content Serve as Predictive Biomarkers for Exit of Tumors from Dormancy?
  Almog N, Klement G. Cancers 2: 842-858, 2010 [Abstract]
   
• Tumor morphological evolution: directed migration and gain and loss of the self-metastatic phenotype.
  Enderling H, Hlatky L, Hahnfeldt P. Biol Direct. 5(1):23, 2010 [Abstract]
   
• Molecular mechanisms underlying tumor dormancy.
  Almog N. Cancer Lett 294(2): 139-46, 2010. [Abstract]
   
• A rapid-mutation approximation for cell population dynamics.
  Sachs RK, Hlatky L. Bull Math Biol 72(2): 359-374, 2010. [Abstract]
   
• Evading tumor evasion: Current concepts and perspectives of anti-angiogenic cancer therapy.
  Abdollahi A, Folkman J. Drug Resist Updat 13(1-2): 16-28, 2010. [Abstract]
   
• Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells.
  Fainaru O, Almog N, Wing Yung C, Nakai K, Montoya-Zavala M, Abollahi A, D'Amato R, Ingber DE. FASEB J 24(5): 1411-1418, 2010. [Abstract]
   
• Modeling progression in radiation-induced lung adenocarcinomas.
  Fakir H, Hofmann W, Sachs RK. Radiat Environ Biophys 49(2): 169-176, 2010. [Abstract]
   

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2009

• Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins.
  Lee TY, Muschal S, Pravda EA, Folkman J, Abdollahi A, Javaherian K. Blood 114(9): 1727-1728, 2009. [Abstract]
   
• Paradoxical Dependencies of Tumor Dormancy and Progression on Basic Cell Kinetics.
  Enderling H, Beheshti A, Anderson A, Chaplain M, Hlatky L, Hahnfeldt P. Cancer Res 69(22): 8814-8822, 2009. [Abstract]
   
• Stochastic population dynamic effects for lung cancer progression.
  Fakir H, Tan W, Hlatky L, Hahnfeldt P, Sachs R. Radiat Res Suppl 172: 383-393, 2009. [Abstract]
   
• A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach.
  Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. Radiat Environ Biophys 48: 263-274, 2009. [Abstract]
   
• A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation.
  Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. Radiat Environ Biophys 48: 275-286, 2009. [Abstract]
   
• Migration rules: tumours are conglomerates of self-metastases.
  Enderling H, Hlatky L, Hahnfeldt P. Br J Cancer 100(12): 1917-1925, 2009. [Abstract]
   
• Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype.
  Almog N, Ma L, Raychowdhury R, Schwager C, Erber R, Short S, Hlatky L, Vajkoczy P, Huber PE, Folkman J, Abdollahi A. Cancer Res 69(3): 836-844, 2009. [Abstract]
   
• The importance of spatial distribution of stemness and proliferation state in determining tumor radioresponse.
  Enderling H, Park D, Hlatky L, Hahnfeldt P. Math Model Nat Phenom 4(3): 117-133, 2009. [Abstract]
   
• Regarding the most recent common ancestor of HIV-1 Group M.
  Parris GE. Med Hypotheses 72(3): 360, 2009. [Abstract]
   
• Cell-cell fusion and cancer: germ-cell cancer and teratomas.
  Parris GE. Med Hypotheses 72(2): 226, 2009. [Abstract]
   
• Immunosuppressive therapy and post-transplant malignancy.
  Domhan S, Zeier M, Abdollahi A. Nephrol Dial Transplant 24(4): 1097-1103, 2009. [Abstract]
   
• Platelets actively sequester angiogenesis regulators.
  Klement GL, Yip TT, Cassiola F, Kikuchi L, Cervi D, Podust V, Italiano JE, Wheatley E, Abou-Slaybi A, Bender E, Almog N, Kieran MW, Folkman J. Blood 113(12): 2835-2842, 2009. [Abstract]
   
• Triggering-response model for radiation-induced bystander effects.
  Fakir H, Hofmann W, Tan WY, Sachs RK. Radiat Res 171(3): 320-331, 2009. [Abstract]
   
• Cancer-causing karyotypes: chromosomal equilibria between destabilizing aneuploidy and stabilizing selection for oncogenic function.
  Li L, McCormack AA, Nicholson JM, Fabarius A, Hehlmann R, Sachs RK, Duesberg PH. Cancer Genet Cytogenet 188(1): 1-25, 2009. [Abstract]
   
• Amyloid-beta protein impairs Ca(2+) release and contractility in skeletal muscle.
  Shtifman A, Ward CW, Laver DR, Bannister ML, Lopez JR, Kitazawa M, Laferla FM, Ikemoto N, Querfurth HW. Neurobiol Aging 31(12): 2080-2090, 2010. [Abstract]
   

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2008

• Chromosomal instability (CIN) leads to clone extinction, not cancer.
  Parris GE. Med Hypotheses. 2008 Dec;71(6):983. [Abstract]
   
• Cell-cell fusion is the rate-limiting step in causation and progression of clinically significant cancers.
  Parris GE. Cancer Genet Cytogenet. 2008 Sep;185(2):113. [Abstract]
   
• 2-deoxy-D-glucose as a potential drug against fusogenic viruses including HIV.
  Parris GE. Med Hypotheses. 2008;70(4):776-82. [Abstract]
   
• Anti-fusion drug candidates that may have beneficial effects against cancer, virus infections and autoimmune disorders.
  Parris GE. Med Hypotheses. 2008;70(2):463. [Abstract]
   
• Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid.
  Domhan S, Muschal S, Schwager C, Morath C, Wirkner U, Ansorge W, Maercker C, Zeier M, Huber PE, Abdollahi A. Mol Cancer Ther. 2008 Jun;7(6):1656-68.[Abstract]
   
• Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy.
  Timke C, Zieher H, Roth A, Hauser K, Lipson KE, Weber KJ, Debus J, Abdollahi A, Huber PE. Clin Cancer Res. 2008 Apr 1;14(7):2210-9. [Abstract]
   
• Systems biology and its potential role in radiobiology.
  Feinendegen L, Hahnfeldt P, Schadt EE, Stumpf M, Voit EO. Radiat Environ Biophys. 2008 Feb;47(1):5-23 [Abstract]
   
• Dependence of invadopodia function on collagen fiber spacing and cross-linking: computational modeling and experimental evidence.
  Enderling H, Alexander NR, Clark ES, Branch KM, Estrada L, Crooke C, Jourquin J, Lobdell N, Zaman MH, Guelcher SA, Anderson AR, Weaver AM. Biophys J. 2008 Sep;95(5):2203-18. [Abstract]
   
• Platelet-associated PF-4 as a biomarker of early tumor growth.
  Cervi D, Yip TT, Bhattacharya N, Podust VN, Peterson J, Abou-Slaybi A, Naumov GN, Bender E, Almog N, Italiano JE Jr, Folkman J, Klement GL. Blood. 2008 Feb 1;111(3):1201-7. [Abstract]
   
• In vivo gene transfer to the CNS using recombinant SV40-derived vectors. Louboutin JP, Agrawal L, Liu B, Strayer DS. Expert Opin Biol Ther. 2008 Sep;8(9):1319-35. [Abstract]
   
• SU11657 enhances radiosensitivity of human meningioma cells.
  Milker-Zabel S, Zabel-du Bois A, Ranai G, Trinh T, Unterberg A, Debus J, Lipson KE, Abdollahi A, Huber PE. Int J Radiat Oncol Biol Phys. 2008 Mar 15;70(4):1213-8 [Abstract]
   
• Ageing is associated with diminished apoptotic cell clearance in vivo.
  Aprahamian T, Takemura Y, Goukassian D, Walsh K. Clin Exp Immunol. 2008 Jun;152(3):448-55. [Abstract]
   
• Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice.
  Lopez JR, Lyckman A, Oddo S, Laferla FM, Querfurth HW, Shtifman A. J Neurochem. 2008 Apr;105(1):262-71. [Abstract]
   

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2007

• Second cancers after fractionated radiotherapy: stochastic population dynamics effects.
  Sachs RK, Shuryak I, Brenner D, Fakir H, Hlatky L, Hahnfeldt P. J Theor Biol 249(3): 518-531, 2007. [Abstract]
   
• Transcriptional network governing the angiogenic switch in human pancreatic cancer.
  Abdollahi A, Schwager C, Kleeff J, Esposito I, Domhan S, Peschke P, Hauser K, Hahnfeldt P, Hlatky L, Debus J, Peters JM, Friess H, Folkman J, Huber PE. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12890-5. [Abstract]
   
• Interpreting chromosome aberration spectra.
  Levy D, Reeder C, Loucas B, Hlatky L, Chen A, Cornforth M, Sachs R. J Comput Biol. 2007 Mar;14(2):144-55. [Abstract]
   
• Subtraction of background damage in PFGE experiments on DNA fragment-size distributions.
  Ponomarev AL, Belli M, Hahnfeldt PJ, Hlatky L, Sachs RK, Cucinotta FA. Radiat Environ Biophys. 2007 Jun;46(2):155-60 [Abstract]
   
• Anti-inflammatory effects of alphav integrin antagonism in acute kidney allograft rejection. Bedke J, Kiss E, Behnes CL, Popovic ZV, Heuser M, Stojanovic T, Sijmonsma T, Huber P, Domhan S, Muschal S, Abdollahi A, Gretz N, Gröne HJ. Am J Pathol. 2007 Oct;171(4):1127-39. [Abstract]
   
• Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo.
  Klenke FM, Abdollahi A, Bertl E, Gebhard MM, Ewerbeck V, Huber PE, Sckell A. BMC Cancer. 2007 Mar 17;7:49. [Abstract]
   
• A mathematical model of breast cancer development, local treatment and recurrence.
  Enderling H, Chaplain MA, Anderson AR, Vaidya JS. J Theor Biol. 2007 May 21;246(2):245-59. [Abstract]
   
• Delivering genes to the organ-localized immune system: long-term results of direct intramarrow transduction.
  Louboutin JP, Liu B, Chekmasova AA, Reyes BA, van Bockstaele EJ, Strayer DS. J Gene Med. 2007 Oct;9(10):843-51. [Abstract]
   
• Enhanced voluntary alcohol consumption after estrogen supplementation negates estrogen-mediated vascular repair in ovariectomized mice.
  Rajasingh J, Bord E, Qin G, Ii M, Silver M, Hamada H, Ahluwalia D, Goukassian D, Zhu Y, Losordo DW, Kishore R. Endocrinology. 2007 Aug;148(8):3618-24. [Abstract]
   
• Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues.
  Shuryak I, Sachs RK, Brenner DJ. Radiat Res. 2007 Dec;168(6):741-9. Erratum in: Radiat Res. 2008 Apr;169(4):481. [Abstract]
   
• Reducing second breast cancers: a potential role for prophylactic mammary irradiation.
  Brenner DJ, Shuryak I, Russo S, Sachs RK. [Abstract]
   
• Individualized estimates of second cancer risks after contemporary radiation therapy for Hodgkin lymphoma.
  Hodgson DC, Koh ES, Tran TH, Heydarian M, Tsang R, Pintilie M, Xu T, Huang L, Sachs RK, Brenner DJ. Cancer. 2007 Dec 1;110(11):2576-86. [Abstract]
   
• Cancer drug resistance: the central role of the karyotype.
  Duesberg P, Li R, Sachs R, Fabarius A, Upender MB, Hehlmann R. Drug Resist Updat. 2007 Feb-Apr;10(1-2):51-8. [Abstract]
   
• A comparison of mantle versus involved-field radiotherapy for Hodgkin's lymphoma: reduction in normal tissue dose and second cancer risk.
  Koh ES, Tran TH, Heydarian M, Sachs RK, Tsang RW, Brenner DJ, Pintilie M, Xu T, Chung J, Paul N, Hodgson DC. Radiat Oncol. 2007 Mar 15;2:13. [Abstract]
   

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