Publications

This is a list of recent representative publications from the group or group members of the CCSB.

   jump to year  2016, 2015, 2014, 2013, 2012, 2011, 2010, 2009, 2008, 2007, 2006.

2016

• Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells.
  Oh J, Hlatky L, Jeong YS, Kim D. Toxins (Basel). 2016 Jun 30;8(7). PMCID: PMC4963832  [Abstract | Open Access]
  
  
• Radiation-Induced Reprogramming of Pre-Senescent Mammary Epithelial Cells Enriches Putative CD44(+)/CD24(-/low) Stem Cell Phenotype.
  Gao X, Sishc BJ, Nelson CB, Hahnfeldt P, Bailey SM, Hlatky L. Front Oncol. 2016 Jun 14;6:138. PMCID: PMC4905979  [Abstract | Open Access]
  
  
• Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma.
  Ravi D, Beheshti A, Abermil N, Passero F, Sharma J, Coyle M, Kritharis A, Kandela I, Hlatky L, Sitkovsky MV, Mazar A, Gartenhaus RB, Evens AM. Cancer Res. 2016 Jun 1;76(11):3319-31. Epub 2016 Mar 17.  [Abstract]
  
  
• Evaluating biomarkers to model cancer risk post cosmic ray exposure.
  Sridharan DM, Asaithamby A, Blattnig SR, Costes SV, Doetsch PW, Dynan WS, Hahnfeldt P, Hlatky L, Kidane Y, Kronenberg A, Naidu MD, Peterson LE, Plante I, Ponomarev AL, Saha J, Snijders AM, Srinivasan K, Tang J, Werner E, Pluth JM. Life Sci Space Res (Amst). 2016 Jun;9:19-47. Epub 2016 May 21.  [Abstract | Open Access]
  

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2015

• Capturing the driving role of tumor-host crosstalk in a dynamical model of tumor growth.
  Benzekry S, Beheshti A, Hahnfeldt P, Hlatky L. Bio-Protocol. 2015 Nov 5;5(21):e1644. PMCID: PMC4957653  [Abstract | Open Access]
  
  
• Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development.
  Beheshti A, Wage J, McDonald JT, Lamont C, Peluso M, Hahnfeldt P, Hlatky L. Oncotarget. 2015 Nov 3;6(34):35419-32. Epub 2015 Oct 21. PMCID: PMC4742115  [Abstract | Open Access]
  
  
• Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue.
  Wage J, Ma L, Peluso M, Lamont C, Evens AM, Hahnfeldt P, Hlatky L, Beheshti A. J Radiat Res. 2015 Sep;56(5):792-803. Epub 2015 Aug 7. PMCID: PMC4577010  [Abstract | Open Access]
  
  
• Biological effects of proton radiation: an update.
  Girdhani S, Sachs R, Hlatky L. Radiat Prot Dosimetry. 2015 Sep;166(1-4):334-8. Epub 2015 Apr 20.  [Abstract]
  
  
• Fractionated radiation exposure of rat spinal cords leads to latent neuro-inflammation in brain, cognitive deficits, and alterations in Apurinic Endonuclease 1.
  Suresh Kumar MA, Peluso M, Chaudhary P, Dhawan J, Beheshti A, Manickam K, Thapar U, Pena L, Natarajan M, Hlatky L, Demple B, Naidu M. PLoS One. 2015 Jul 24;10(7):e0133016. PMCID: PMC4514622  [Abstract | Open Access]
  
  
• Concepts and challenges in cancer risk prediction for the space radiation environment.
  Barcellos-Hoff MH, Blakely EA, Burma S, Fornace AJ Jr, Gerson S, Hlatky L, Kirsch DG, Lederer U, Shay J, Wang Y, Weil MM. Life Sci Space Res (Amst). 2015 Jul;6:92-103. Epub 2015 Jul 17.  [Abstract | Open Access]
  
  
• Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks.
  Benzekry S, Tuszynski JA, Rietman EA, Lakka Klement G. Biol Direct. 2015 May 28;10:32. PMCID: PMC4445818  [Abstract | Open Access]
  
  
• Therapeutic implications from sensitivity analysis of tumor angiogenesis models.
  Poleszczuk J, Hahnfeldt P, Enderling H. PLoS One. 2015 Mar 18;10(3):e0120007. PMCID: PMC4364928  [Abstract | Open Access]
  
  
• Host age is a systemic regulator of gene expression impacting cancer progression.
  Beheshti A, Benzekry S, McDonald JT, Ma L, Peluso M, Hahnfeldt P, Hlatky L. Cancer Res. 2015 Mar 15;75(6):1134-43. Epub 2015 Mar 2. PMCID: PMC4397972  [Abstract | Open Access]
  
  
• Evolution and phenotypic selection of cancer stem cells.
  Poleszczuk J, Hahnfeldt P, Enderling H. PLoS Comput Biol. 2015 Mar 5;11(3):e1004025. PMCID: PMC4351192  [Abstract | Open Access]
  
  
• Stochastic process pharmacodynamics: dose timing in neonatal gentamicin therapy as an example.
  Radivoyevitch T, Siranart N, Hlatky L, Sachs R. AAPS J. 2015 Mar;17(2):447-56. Epub 2015 Feb 7. PMCID: PMC4365091  [Abstract | Open Access ]
  
  
• Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme.
  Chowdhury SM, Surhland C, Sanchez Z, Chaudhary P, Suresh Kumar MA, Lee S, Peña LA, Waring M, Sitharaman B, Naidu M. Nanomedicine. 2015 Jan;11(1):109-18. Epub 2014 Aug 13. PMCID: PMC4280300  [Abstract | Open Access]
  

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2014

• Distinct luminal-type mammary carcinomas arise from orthotopic Trp53-null mammary transplantation of juvenile versus adult mice.
  Nguyen DH, Ouyang H, Mao JH, Hlatky L, Barcellos-Hoff MH. Cancer Res. 2014 Dec 1;74(23):7149-58. Epub 2014 Oct 3. PMCID: PMC4252877  [Abstract | Open Access]
  
  
• Why is there so much therapy-related AML and MDS and so little therapy-related CML?
  Gale RP, Hlatky L, Sachs RK, Radivoyevitch T. Leuk Res. 2014 Oct;38(10):1162-4. Epub 2014 Aug 11.  [Abstract]
  
  
• The Power of the Tumor Microenvironment: A Systemic Approach for a Systemic Disease.
  Kareva I, Wilkie KP, Hahnfeldt P. In: d'Onofrio A, Gandolfi A (eds). Mathematical Oncology 2013. Birkhäuser Basel, 2014:181-196. In Series: Modeling and Simulation in Science, Engineering and Technology: Bellomo N (series ed).  [Abstract]
  
  
• A mathematical model of systemic inhibition of angiogenesis in metastatic development.
  Benzekry S, Gandolfi A, Hahnfeldt P. Congrès SMAI 2013. ESAIM Proc Surv. 2014 Sept;45:75-87. Epub 2014 Nov 13.  [Abstract | Open Access PDF]
  
  
• Classical mathematical models for description and prediction of experimental tumor growth.
  Benzekry S, Lamont C, Beheshti A, Tracz A, Ebos JM, Hlatky L, Hahnfeldt P. PLoS Comput Biol. 2014 Aug 28;10(8):e1003800. eCollection 2014. PMCID: PMC4148196  [Abstract | Open Access]
  
  
• A multicompartment mathematical model of cancer stem cell-driven tumor growth dynamics.
  Weekes SL, Barker B, Bober S, Cisneros K, Cline J, Thompson A, Hlatky L, Hahnfeldt P, Enderling H. Bull Math Biol. 2014 Jul;76(7):1762-82. Epub 2014 May 20. PMCID: PMC4140966  [Abstract]
  
  
• Mathematical modeling of tumor growth and treatment.
  Enderling H, Chaplain MA. Curr Pharm Des. 2014;20(30):4934-40. Epub 2013 Nov 25.  [Abstract]
  
  
• Tumor dormancy and the angiogenic switch: possible implications of bone marrow-derived cells.
  Shaked Y, McAllister S, Fainaru O, Almog N. Curr Pharm Des. 2014;20(30):4920-33. Epub 2013 Nov 25.  [Abstract]
  
  
• Addition of platelet concentrate to Dermo-Epidermal Skin Graft in deep burn trauma reduces scarring and need for revision surgeries.
  Prochazka V, Klosova H, Stetinsky J, Gumulec J, Vitkova K, Salounova D, Dvorackova J, Bielnikova H, Klement P, Levakova V, Ocelka T, Pavliska L, Kovanic P, Klement GL. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014 Jun;158(2):242-58. Epub 2013 Sep 27.  [Abstract | Open Access]
  
  
• TNF-TNFR2/p75 signaling inhibits early and increases delayed non-targeted effects in bone marrow-derived endothelial progenitor cells.
  Sasi SP, Song J, Park D, Enderling H, McDonald JT, Gee H, Garrity B, Shtifman A, Yan X, Walsh K, Natarajan M, Kishore R, Goukassian DA. J Biol Chem. 2014 May 16;289(20):14178-93. Epub 2014 Apr 7. PMCID: PMC4022885  [Abstract | Open Access]
  
  
• Biphasic modulation of cancer stem cell-driven solid tumour dynamics in response to reactivated replicative senescence.
  Poleszczuk J, Hahnfeldt P, Enderling H. Cell Prolif. 2014 Jun;47(3):267-76. Epub 2014 Mar 25.  [Abstract]
  
  
• A proposed quantitative index for assessing the potential contribution of reprogramming to cancer stem cell kinetics.
  Gao X, McDonald JT, Naidu M, Hahnfeldt P, Hlatky L. Stem Cells Int. 2014;2014:249309. Epub 2014 May 12. PMCID: PMC4052692  [Abstract | Open Access]
  
  
• A quest to identify prostate cancer circulating biomarkers with a bench-to-bedside potential.
  Batra JS, Girdhani S, Hlatky L. J Biomark. 2014 Mar 12;2014:321680. Epub 2014 Jan 10. PMCID: PMC4437363  [Abstract | Open Access]
  
  
• TNF-α and IL-1α but not MCP-1 and Rantes increase significantly the formation of p-H2AX foci in naïve BM-derived TNFR1/p55KO EPCs.
  Sasi SP, Song J, Enderling H, Yan X, Goukassian DA. J Radiat Res. 2014 Mar 1;55 Suppl 1:i122-i123. PMCID: PMC3941533  [Abstract | Open Access]
  
  
• ⁵⁶Fe ion irradiation enhances angiogenesis and other inter-cellular determinants of carcinogenesis risk.
  Girdhani S, Lamont C, Peluso M, Sun M, Hlatky L. J Radiat Res. 2014 Mar 1;55 Suppl 1:i124-i126. PMCID: PMC3941549  [Abstract | Open Access]
  
  
• Proton irradiation augments the suppression of tumor progression observed with advanced age.
  Beheshti A, Peluso M, Lamont C, Hahnfeldt P, Hlatky L. Radiat Res. 2014 Mar;181(3):272-83. Epub 2014 Feb 25. PMCID: PMC4406472  [Abstract]   COVER ARTICLE
  
  
• Chronic low dose-rate radiation down-regulates transcription related to mitosis and chromosomal movement similar to acute high dose in prostate cells.
  McDonald JT, Briggs C, Szelag H, Peluso M, Schneider D, Perepletchikov A, Klement GL, Tuerk I, Hlatky L. Int J Radiat Biol. 2014 Mar;90(3):231-40. Epub 2014 Jan 8.  [Abstract]
  
  
• Sonic hedgehog therapy in a mouse model of age-associated impairment of skeletal muscle regeneration.
  Piccioni A, Gaetani E, Neri V, Gatto I, Palladino M, Silver M, Smith RC, Giarretta I, Pola E, Hlatky L, Pola R. J Gerontol A Biol Sci Med Sci. 2014 Mar;69(3):245-52. Epub 2013 Jun 18. PMCID: PMC3976139  [Abstract | Open Access]   EDITOR'S CHOICE selection
  
  
• Sex differences in the incidence of chronic myeloid leukemia.
  Radivoyevitch T, Jankovic GM, Tiu RV, Saunthararajah Y, Jackson RC, Hlatky LR, Gale RP, Sachs RK. Radiat Environ Biophys. 2014 Mar;53(1):55-63. Epub 2013 Dec 13. PMCID: PMC3943788  [Abstract]
  
  
• Beyond the cancer cell: progression-level determinants highlight the multi-scale nature of carcinogenesis risk.
  Hlatky L, Hahnfeldt P. Cancer Res. 2014 Feb 1;74(3):659-64. Epub 2013 Nov 22.  [Abstract | Open Access]
  
  
• Global dormancy of metastases due to systemic inhibition of angiogenesis.
  Benzekry S, Gandolfi A, Hahnfeldt P. PLoS One. 2014 Jan 21;9(1):e84249. eCollection 2014 Jan 21. PMCID: PMC3897365  [Abstract | Open Access]
  
  
• [Platelets in the pathogenesis of solid tumors]. (Article in Czech)
  Bencsiková B, Greplová K, Pilátová K, Volejníková Z, Valík D, Klement GL, Zdražilová-Dubská L. Cas Lek Cesk. 2014;153(2):78-85. Czech.  [Abstract]
  
  
• A Review and Perspective on Thermodynamics Applied to Molecular Systems and Cancer Biology.
  Rietman EA, Hahnfeldt P, Hlatky L. In: Valente AX, Sarkar A, Gao Y (eds). Recent Advances in Systems Biology Research. Nova Science Publishers, Inc., 2014:49-78. In Series: Systems Biology – Theory, Techniques and Applications.
  
  
• Radiotherapy-Induced Carcinogenesis and Leukemogenesis: Mechanisms and Quantitative Modeling.
  Brenner D, Shuryak I, Sachs RK. In: Rubin P, Constine LS, Marks LB (eds). ALERT – Adverse Late Effects of Cancer Treatment. Volume 1: General Concepts and Specific Precepts. New York: Springer, 2014:205-226. In Series: Medical Radiology – Radiation Oncology: Brady LW, Heilmann H-P, Molls M, Nieder C (series eds).  [Abstract]

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2013

• Repopulation of interacting tumor cells during fractionated radiotherapy: Stochastic modeling of the tumor control probability.
  Fakir H, Hlatky L, Li H, Sachs R. Med Phys. 2013 Dec;40(12):121716. Epub 2013 Nov 15. PMCID: PMC3843751  [Abstract | Open Access]   EDITOR'S PICKS selection
  
  
• Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy.
  Palladino M, Gatto I, Neri V, Straino S, Smith RC, Silver M, Gaetani E, Marcantoni M, Giarretta I, Stigliano E, Capogrossi M, Hlatky L, Landolfi R, Pola R. Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2867-76. Epub 2013 Sep 26.  [Abstract | Open Access]
  
  
• Early tumor development captured through nondestructive, high resolution differential phase contrast X-ray imaging.
  Beheshti A, Pinzer BR, McDonald JT, Stampanoni M, Hlatky L. Radiat Res. 2013 Nov;180(5):448-54. Epub 2013 Oct 14. PMCID: PMC3925470  [Abstract]
  
  
• Maximum tolerated dose versus metronomic scheduling in treatment of metastatic cancers.
  Benzekry S, Hahnfeldt P. J Theor Biol. 2013 Oct 21;335:235-44. Epub 2013 Jul 11.  [Abstract]
  
  
• Formalizing an integrative, multidisciplinary cancer therapy discovery workflow.
  McGuire MF, Enderling H, Wallace DI, Batra J, Jordan M, Kumar S, Panetta JC, Pasquier E. Cancer Res. 2013 Oct 15;73(20):6111-7. Epub 2013 Aug 16. PMCID: PMC4040396  [Abstract | Open Access]
  
  
• Tumors as organs: biologically augmenting radiation therapy by inhibiting transforming growth factor β activity in carcinomas.
  Du S, Barcellos-Hoff MH. Semin Radiat Oncol. 2013 Oct;23(4):242-51. PMCID: PMC3951811  [Abstract]
  
  
• Simulating cancer: computational models in oncology.
  Enderling H, Rejniak KA. Front Oncol. 2013 Sep 13;3:233. PMCID: PMC3772565  [Abstract | Open Access]
  
  
• Multiple effects of β-amyloid on single excitatory synaptic connections in the PFC.
  Wang Y, Zhou TH, Zhi Z, Barakat A, Hlatky L, Querfurth H. Front Cell Neurosci. 2013 Sep 3;7:129. PMCID: PMC3759796  [Abstract | Open Access]
  
  
• Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion.
  Wilkie KP, Hahnfeldt P. Interface Focus. 2013 Aug 6;3(4):20130010. Epub 2013 Jun 25. PMCID: PMC3915830  [Abstract | Open Access]
  
  
• Theoretical Biology and Medical Modelling: ensuring continued growth and future leadership.
  Nishiura H, Rietman EA, Wu R. Theor Biol Med Model. 2013 Jul 11;10:43. PMCID: PMC3710265  [Abstract | Open Access]
  
  
• Transcriptional changes induced by the tumor dormancy-associated microRNA-190.
  Almog N, Briggs C, Beheshti A, Ma L, Wilkie KP, Rietman E, Hlatky L. Transcription. 2013 Jul 1;4(4). PMCID: PMC3977918  [Abstract | Open Access]   COVER ARTICLE
  
  
• Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology.
  Pilatova K, Greplova K, Demlova R, Bencsikova B, Klement GL, Zdrazilova-Dubska L. J Hematol Oncol. 2013 Jun 24;6:42. PMCID: PMC3694472  [Abstract | Open Access]
  
  
• Tumor–immune dynamics regulated in the microenvironment inform the transient nature of immune-induced tumor dormancy.
  Wilkie KP, Hahnfeldt P. Cancer Res. 2013 Jun 15;73(12):3534-44. Epub 2013 Mar 27. PMCID: PMC3955200  [Abstract | Open Access]
  
  
• Engineering cell-fluorescent ion track hybrid detectors.
  Niklas M, Grellich S, Melzig C, Akselrod MS, Debus J, Jäkel O, Abdollahi A. Radiat Oncol. 2013 Jun 11;8:141. PMCID: PMC3699405  [Abstract | Open Access]
  
  
• An integrated multidisciplinary model describing initiation of cancer and the Warburg hypothesis.
  Rietman EA, Friesen DE, Hahnfeldt P, Gatenby R, Hlatky L, Tuszynski JA. Theor Biol Med Model. 2013 Jun 10;10:39. PMCID: PMC3689044  [Abstract | Open Access]
  
  
• Modeling the Dichotomy of the Immune Response to Cancer: Cytotoxic Effects and Tumor-Promoting Inflammation.
  Wilkie KP, Hahnfeldt P. arXiv:1305.3634 [q-bio.CB]. 2013 May 15.  [Abstract]
  
  
• Center of Cancer Systems Biology Second Annual Workshop — Tumor Metronomics: Timing and Dose Level Dynamics.
  Hahnfeldt P, Hlatky L, Klement GL. Cancer Res. 2013 May 15;73(10):2949-54. Epub 2013 Mar 14. PMCID: PMC3696500  [Abstract | Open Access]
  
  
• The emerging “hallmarks” of metabolic reprogramming and immune evasion: distinct or linked?
  Kareva I, Hahnfeldt P. Cancer Res. 2013 May 1;73(9):2737-42. Epub 2013 Feb 19.  [Abstract | Open Access]
  
  
• Rapid and automated multidimensional fluorescence microscopy profiling of 3D human breast cultures.
  Park CC, Georgescu W, Polyzos A, Pham C, Ahmed KM, Zhang H, Costes SV. Integr Biol (Camb). 2013 Apr 25;5(4):681-91. Epub 2013 Feb 13. PMCID: PMC3641787  [Abstract]
  
  
• Cancer stem cells: a minor cancer subpopulation that redefines global cancer features.
  Enderling H, Hlatky L, Hahnfeldt P. Front Oncol. 2013 Apr 15;3:76. Epub 2013 Apr 15. PMCID: PMC3625721  [Abstract | Open Access]
  
  
• Modelling c-Abl signalling in activated neutrophils: the anti-inflammatory effect of seliciclib.
  Jackson RC, Radivoyevitch T. Biodiscovery. 2013 March 1;7(4):4. PMCID: PMC3994723  [Abstract | Open Access]
  
  
• Theoretical investigation of the efficacy of antiangiogenic drugs combined to chemotherapy in xenografted mice.
  Lignet F, Benzekry S, Wilson S, Billy F, Saut O, Tod M, You B, Adda Berkane A, Kassour S, Wei MX, Grenier E, Ribba B. J Theor Biol. 2013 Mar 7;320:86-99. Epub 2012 Dec 21.  [Abstract]
  
  
• Acute and fractionated irradiation differentially modulate glioma stem cell division kinetics.
  Gao X, McDonald JT, Hlatky L, Enderling H. Cancer Res. 2013 Mar 1;73(5):1481-90. Epub 2012 Dec 26. PMCID: PMC3594421  [Abstract | Open Access]
  
  
• Biological effects of proton radiation: what we know and don't know.
  Girdhani S, Sachs R, Hlatky L. Radiat Res. 2013 Mar;179(3):257-72. Epub 2013 Feb 1.  [Abstract]   COVER ARTICLE
  
  
• Increased CDA expression/activity in males contributes to decreased cytidine analog half-life and likely contributes to worse outcomes with 5-azacytidine or decitabine therapy.
  Mahfouz RZ, Jankowska A, Ebrahem Q, Gu X, Visconte V, Tabarroki A, Terse P, Covey J, Chan K, Ling Y, Engelke KJ, Sekeres MA, Tiu R, Maciejewski J, Radivoyevitch T, Saunthararajah Y. Clin Cancer Res. 2013 Feb 15;19(4):938-48. Epub 2013 Jan 3. PMCID: PMC3577958  [Abstract | Open Access]
  
  
• Age and space irradiation modulate tumor progression: implications for carcinogenesis risk.
  Beheshti A, Sachs RK, Peluso M, Rietman E, Hahnfeldt P, Hlatky L. Radiat Res. 2013 Feb;179(2):208-20. Epub 2013 Jan 4.  [Abstract]
  
  
• Biological stoichiometry in tumor micro-environments.
  Kareva I. PLoS One. 2013;8(1):e51844. Epub 2013 Jan 22. PMCID: PMC3551943  [Abstract | Open Access]
  
  
• Organism mutation stability and cancer.
  Rietman EA, McDonald JT, Hlatky L. In: Shoja MM, Agutter PS, Tubbs RS, Ghanei M, Ghabili K, Harris A, Loukas M (eds). Hypotheses in Clinical Medicine. Nova Science Publishers, Inc., 2013:135-46.  [Abstract]
  
  
• The tumor growth paradox and immune system-mediated selection for cancer stem cells.
  Hillen T, Enderling H, Hahnfeldt P. Bull Math Biol. 2013 Jan;75(1):161-84. Epub 2012 Nov 30.  [Abstract]
  
  
• Systems Biology of Tumor Dormancy.
  Enderling H, Almog N, Hlatky L, editors. New York: Springer, 2013: 291p. In Series: Advances in Experimental Medicine and Biology, Vol. 734.
  
  
• Genes and Regulatory Pathways Involved in Persistence of Dormant Micro-tumors.
  Almog N. Adv Exp Med Biol. 2013;734:3-17.  [Abstract]
  
  
• The host support niche as a control point for tumor dormancy: implications for tumor development and beyond.
  Hahnfeldt P. Adv Exp Med Biol. 2013;734:19-35.  [Abstract]
  
  
• Cancer stem cells and tumor dormancy.
  Enderling H. Adv Exp Med Biol. 2013;734:55-71.  [Abstract]
  
  
• A review of mathematical models of cancer-immune interactions in the context of tumor dormancy.
  Wilkie KP. Adv Exp Med Biol. 2013;734:201-34.  [Abstract]
  
  
• Historical perspective of cell-cell fusion in cancer initiation and progression.
  Parris GE. Crit Rev Oncog. 2013;18(1-2):1-18.  [Abstract]
  
  
• Chapter 24 – The Role of Platelets in Angiogenesis.
  Klement GL, Shai E, Varon D. In: Michelson A (ed). Platelets. Third Edition. Waltham, MA: Academic Press (Elsevier Science), 2013:487-502.  [Abstract]
  

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2012

• Radiation-induced cancer: a modern view.
  Shah DJ, Sachs RK, Wilson DJ. Br J Radiol. 2012 Dec;85(1020):e1166-73. PMCID: PMC3611719  [Abstract | Open Access]
  
  
• Cell-Cell Interactions in Solid Tumors — the Role of Cancer Stem Cells.
  Gao X, McDonald JT, Hlatky L, Enderling H. In: D'Onofrio A, Cerrai P, Gandolfi A (eds). New Challenges for Cancer Systems Biomedicine. Milan, Italy: Springer, 2012:191-204. In Series: SIMAI Springer Series: Bellomo N, Formaggia L, Bangerth W, Nobile F, Pareschi L, Tercero PP, Tosin A, Zubelli JP (series eds).  [Abstract]
  
  
• The role of platelets in tumour growth.
  Pilatova K, Zdrazilova-Dubska L, Klement GL. Klin Onkol. 2012;25(Suppl 2):2S50-7.  [Abstract | Open Access]
  
  
• Topical application of thymidine dinucleotide to newborn mice reduces and delays development of UV-induced melanomas.
  Goukassian DA, Sharov A, Rhodes J, Coleman C, Eller MS, Sharova T, Bhawan J, Gilchrest BA. J Invest Dermatol. 2012 Nov;132(11):2664-6. Epub 2012 Jun 14. PMCID: PMC3443549  [Abstract | Open Access]
  
  
• Breaking the ‘harmony’ of TNF-α signaling for cancer treatment.
  Sasi SP, Yan X, Enderling H, Park D, Gilbert HY, Curry C, Coleman C, Hlatky L, Qin G, Kishore R, Goukassian DA. Oncogene. 2012 Sep 13;31(37):4117-27. Epub 2011 Dec 12. PMCID: PMC3962797  [Abstract | Open Access]
  
  
• Prospective identification of glioblastoma cells generating dormant tumors.
  Satchi-Fainaro R, Ferber S, Segal E, Ma L, Dixit N, Ijaz A, Hlatky L, Abdollahi A, Almog N. PLoS One. 2012;7(9):e44395. Epub 2012 Sep 6. PMCID: PMC3435314  [Abstract | Open Access]
  
  
• Consensus micro RNAs governing the switch of dormant tumors to the fast-growing angiogenic phenotype.
  Almog N, Ma L, Schwager C, Brinkmann BG, Beheshti A, Vajkoczy P, Folkman J, Hlatky L, Abdollahi A. PLoS One. 2012;7(8):e44001. Epub 2012 Aug 31. PMCID: PMC3432069  [Abstract | Open Access]
  
  
• Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.
  Hardee ME, Marciscano AE, Medina-Ramirez CM, Zagzag D, Narayana A, Lonning SM, Barcellos-Hoff MH. Cancer Res. 2012 Aug 15;72(16):4119-29. Epub 2012 Jun 12. PMCID: PMC3538149  [Abstract | Open Access]
  
  
• Combined therapy with sonic hedgehog gene transfer and bone marrow-derived endothelial progenitor cells enhances angiogenesis and myogenesis in the ischemic skeletal muscle.
  Palladino M, Gatto I, Neri V, Stigliano E, Smith RC, Pola E, Straino S, Gaetani E, Capogrossi M, Leone G, Hlatky L, Pola R. J Vasc Res. 2012;49(5):425-31. Epub 2012 Jun 22.  [Abstract | Open Access]
  
  
• Immunoediting: evidence of the multifaceted role of the immune system in self-metastatic tumor growth.
  Enderling H, Hlatky L, Hahnfeldt P. Theor Biol Med Model. 2012 Jul 28;9(1):31. Epub 2012 Jul 28. PMCID: PMC3499182  [Abstract | Open Access]
  
  
• Proton irradiation suppresses angiogenic genes and impairs cell invasion and tumor growth.
  Girdhani S, Lamont C, Hahnfeldt P, Abdollahi A, Hlatky L. Radiat Res. 2012 Jul;178(1):33-45. Epub 2012 Jun 14.  [Abstract]
  
  
• Cancer therapy targeting the HER2-PI₃K pathway: potential impact on the heart.
  Klement GL, Goukassian D, Hlatky L, Carrozza J, Morgan JP, Yan X. Front Pharmacol. 2012 Jun 27;3:113. Epub 2012 Jun 27. PMCID: PMC3384262  [Abstract | Open Access]
  
  
• Molecular signaling network complexity is correlated with cancer patient survivability.
  Breitkreutz D, Hlatky L, Rietman E, Tuszynski JA. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9209-12. Epub 2012 May 21. PMCID: PMC3384193  [Abstract | Open Access]
  
  
• Identification of stable endogenous control genes for transcriptional profiling of photon, proton and carbon-ion irradiated cells.
  Sharungbam GD, Schwager C, Chiblak S, Brons S, Hlatky L, Haberer T, Debus J, Abdollahi A. Radiat Oncol. 2012 May 17;7(1):70. PMCID: PMC3422209  [Abstract | Open Access]
  
  
• Quantitative modeling of chronic myeloid leukemia: insights from radiobiology.
  Radivoyevitch T, Hlatky, L, Landaw J, Sachs RK. Blood. 2012 May 10;119(19):4363-71. Epub 2012 Feb 21. PMCID: PMC3362357  [Abstract | Open Access]   COVER ARTICLE
  
  
• Systems biology of tumor dormancy: linking biology and mathematics on multiple scales to improve cancer therapy.
  Enderling H, Hahnfeldt P, Hlatky L, Almog N. Cancer Res. 2012 May 1;72(9):2172-5. Epub 2012 Mar 13. PMCID: PMC3374524  [Abstract | Open Access]
  
  
• The promoting role of a tumour-secreted chemorepellent in self-metastatic tumour progression.
  Enderling H, Hlatky L, Hahnfeldt P. Math Med Biol. 2012 Mar;29(1):21-9. Epub 2010 Oct 6.  [Abstract]
  
  
• Double-strand break motions shift radiation risk notions?
  Hlatky, L. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):3511-2. Epub 2011 Dec 30. PMCID: PMC3258590  [Abstract | Open Access]
  
  
• Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets.
  Etulain J, Negrotto S, Carestia A, Pozner RG, Romaniuk MA, D'Atri LP, Klement GL, Schattner M. Thromb Haemost. 2012 Jan;107(1):99-110. Epub 2011 Dec 8.  [Abstract]
  
  
• A mathematical investigation of the role of intracranial pressure pulsations and small gradients in the pathogenesis of hydrocephalus.
  Wilkie KP, Drapaca CS, Sivaloganathan S. Int J Numer Anal Model B. 2012;3(1):36-51. PMCID: PMC4286312  [Abstract | PDF]
  
  
• A mathematical analysis of physiological and molecular mechanisms that modulate pressure gradients and facilitate ventricular expansion in hydrocephalus.
  Wilkie KP, Nagra G, Johnston M. Int J Numer Anal Model B. 2012;3(1):65-81. PMCID: PMC4322945  [Abstract | PDF]
  
  
• Isolation and Proteomic Analysis of Platelets by SELDI-TOF MS.
  Downing SR, Klement, GL. In: Clarke CH, McCarthy DLB (eds). SELDI-TOF Mass Spectrometry. Methods and Protocols. New York: Springer, 2012:153-70. In Series: Methods in Molecular Biology, Vol. 818.  [Abstract]
  

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2011

• Non-stem cancer cell kinetics modulate solid tumor progression.
  Morton CI, Hlatky, L, Hahnfeldt P, Enderling, H. Theor Biol Med Model. 2011 Dec 30;8(1):48. Epub 2011 Dec 30. PMCID: PMC3285090  [Abstract | Open Access]
  
  
• Improvement in the standard treatment for experimental glioma by fusing antibody Fc domain to endostatin.
  Grossman R, Tyler B, Hwang L, Zadnik P, Lal B, Javaherian K, Brem H. J Neurosurg. 2011 Dec;115(6):1139-46. Epub 2011 Sep 16.  [Abstract | Open Access ]
  
  
• Two endogenous antiangiogenic inhibitors, endostatin and angiostatin, demonstrate biphasic curves in their antitumor profiles.
  Javaherian K, Lee TY, Tjin Tham Sjin RM, Parris GE, Hlatky L. Dose Response. 2011;9(3):369-76. Epub 2010 Oct 21. PMCID: PMC3186931  [Abstract | Open Access]
  
  
• Platelet biomarkers in tumor growth.
  Klement GL. Curr Proteomics. 2011;8(3):169-80.  [Abstract]
  
  
• Cancer stem cells in solid tumors: is ‘evading apoptosis’ a hallmark of cancer?
  Enderling H, Hahnfeldt P. Prog Biophys Mol Biol. 2011 Aug;106:391-9.  [Abstract]
  
  
• Hyperthermia inhibits platelet hemostatic functions and selectively regulates the release of alpha-granule proteins.
  Etulain J, Lapponi MJ, Patrucchi SJ, Romaniuk MA, Benzadón R, Klement GL, Negrotto S, Schattner M. J Thromb Haemost. 2011 Aug;9(8):1562-71. PMCID: PMC3155010  [Abstract | Open Access]
  
  
• Evidence for network evolution in an Arabidopsis interactome map.
  Arabidopsis Interactome Mapping Consortium [Rietman EA]. Science. 2011 Jul 29;333(6042):601-7. PMCID: PMC3170756  [Abstract]
  
  
• Intercellular communication by exchange of cytoplasmic material via tunneling nano-tube like structures in primary human renal epithelial cells.
  Domhan S, Ma L, Tai A, Anaya Z, Beheshti Z, Zeier M, Hlatky L, Abdollahi A. PLoS One. 2011;6(6):e21283. Epub 2011 Jun 27. PMCID: PMC3124493  [Abstract | Open Access]
  
  
• Review and application of group theory to molecular systems biology.
  Rietman EA, Karp RL, Tuszynski JA. Theor Biol Med Model. 2011 Jun 22;8:21. PMCID: PMC3149578  [Abstract | Open Access]
  
  
• Interactomes, manufacturomes and relational biology: analogies between systems biology and manufacturing systems.
  Rietman EA, Colt JZ, Tuszynski JA. Theor Biol Med Model. 2011 Jun 20;8:19. PMCID: PMC3145567  [Abstract | Open Access]
  
  
• Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling.
  Tang J, Enderling H, Becker-Weimann S, Pham C, Polyzos A, Chen CY, Costes SV. Integr Biol (Camb). 2011 Apr;3(4):408-21. PMCID: PMC4009383  [Abstract | Open Access]   COVER ARTICLE
  
  
• Low-dose radiation knowledge worth the cost.
  Barcellos-Hoff MH, Brenner DJ, Brooks AL, Formenti S, Hlatky L, Locke PA, Shore R, Tenforde T, Travis El, Williams J. Science. 2011 Apr 15;332(6027):305-6.  [Abstract]
  
  
• A multicellular basis for the origination of blast crisis in chronic myeloid leukemia.
  Sachs RK, Johnsson K, Hahnfeldt P, Luo J, Chen A, Hlatky L. Cancer Res. 2011 Apr 15;71(8):2838-47. Epub 2011 Apr 12. PMCID: PMC3537493  [Abstract | Open Access]
  
  
• A new view of radiation-induced cancer.
  Shuryak I, Sachs RK, Brenner DJ. Radiat Prot Dosimetry. 2011 Feb;143(2-4):358-64. Epub 2010 Nov 27. PMCID: PMC3108273  [Abstract]
  

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2010

• Quantitative modeling of tumor dynamics and radiotherapy.
  Enderling H, Chaplain MAJ, Hahnfeldt P. Acta Biotheor. 2010 Dec;58(4):341-53. Epub 2010 Jul 24.  [Abstract]
  
  
• Cancer risks after radiation exposure in middle age.
  Shuryak I, Sachs RK, Brenner DJ. J Natl Cancer Inst. 2010 Nov 3;102(21):1628-36. Epub 2010 Oct 25. PMCID: PMC2970575  [Abstract | Open Access]
  
  
• Ionizing radiation activates the Nrf2 antioxidant response.
  McDonald JT, Kim K, Norris AJ, Vlashi E, Phillips TM, Lagadec C, Della Donna L, Ratikan J, Szelag H, Hlatky L, McBride WH. Cancer Res. 2010 Nov 1;70(21):8886-95. Epub 2010 Oct 12. PMCID: PMC2970706  [Abstract | Open Access]
  
  
• Whole blood transcriptomics in cardiac surgery identifies a gene regulatory network connecting ischemia reperfusion with systemic inflammation.
  Liangos O, Domhan S, Schwager C, Zeier M, Huber PE, Addabbo F, Goligorsky MS, Hlatky L, Jaber BL, Abdollahi A. PLoS One. 2010 Oct 27;5(10):e13658. PMCID: PMC2965092  [Abstract | Open Access]
  
  
• The balance between initiation and promotion in radiation-induced murine carcinogenesis.
  Shuryak I, Ullrich RL, Sachs RK, Brenner DJ. Radiat Res. 2010 Sep;174(3):357-66. PMCID: PMC3570813  [Abstract]
  
  
• Molecular mechanisms underlying tumor dormancy.
  Almog N. Cancer Lett. 2010 Aug 28;294(2):139-46. Epub 2010 Apr 2.  [Abstract]
  
  
• Comment on “Methylmagnesium Alkoxide Clusters with Mg₄O₄ Cubane- and Mg₇O₈ Biscubane-Like Cores: Organometallic Precursors for Low-Temperature Formation of MgO Nanoparticles with Variable Surface Defects”.
  Parris GE. Chem Mater. 2010 Aug 10;22(15):4512. Epub 2010 Jul 12.  [Abstract]
  
  
• Speciation in Anopheles gambiae is consistent with the predictions of the Master Development Program.
  Parris GE. Med Hypotheses. 2010 Jul;75(1):135-6. Epub 2010 Mar 12.  [Abstract]
  
  
• Platelet proteome and tumor dormancy: can platelets content serve as predictive biomarkers for exit of tumors from dormancy?
  Almog N, Klement GL. Cancers (Basel). 2010 May 11;2(2):842-58. PMCID: PMC3835108  [Abstract | Open Access]
  
  
• Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells.
  Fainaru O, Almog N, Yung CW, Nakai K, Montoya-Zavala M, Abollahi A, D'Amato R, Ingber DE. FASEB J. 2010 May;24(5):1411-8. Epub 2009 Dec 14. PMCID: PMC2879945  [Abstract | Open Access]
  
  
• Modeling progression in radiation-induced lung adenocarcinomas.
  Fakir H, Hofmann W, Sachs RK. Radiat Environ Biophys. 2010 May;49(2):169-76. Epub 2010 Jan 8. PMCID: PMC2855436  [Abstract | Open Access]
  
  
• Significance of tumor self-seeding as an augmentation to the classic metastasis paradigm.
  Hahnfeldt P. Future Oncol. 2010 May;6(5):681-5.  [Abstract | Open Access]
  
  
• Scope of medical implications of the Master Development Program hypothesis.
  Parris GE. Med Hypotheses. 2010 May;74(5):953. Epub 2009 Dec 23.  [Abstract]
  
  
• Tumor morphological evolution: directed migration and gain and loss of the self-metastatic phenotype.
  Enderling H, Hlatky L, Hahnfeldt P. Biol Direct. 2010 Apr 20;5(1):23. PMCID: PMC2868833  [Abstract | Open Access]
  
  
• HSPG-binding peptide corresponding to the exon 6a-encoded domain of VEGF inhibits tumor growth by blocking angiogenesis in murine model.
  Lee TY, Folkman J, Javaherian K. PLoS One. 2010 April 1;5(4):e9945. PMCID: PMC2848586  [Abstract | Open Access]
  
  
• MicroRNA expression after ionizing radiation in human endothelial cells.
  Wagner-Ecker M, Schwager C, Wirkner U, Abdollahi A, Huber PE. Radiat Oncol. 2010 Mar 26;5:25. PMCID: PMC2859352  [Abstract | Open Access]
  
  
• Developmental diseases and the hypothetical Master Development Program.
  Parris GE. Med Hypotheses. 2010 Mar;74(3):564-73. Epub 2009 Oct 14.  [Abstract]
  
  
• Evading tumor evasion: current concepts and perspectives of anti-angiogenic cancer therapy.
  Abdollahi A, Folkman J. Drug Resist Updat. 2010 Feb-Apr;13(1-2):16-28. Epub 2010 Jan 12.  [Abstract]
  
  
• A rapid-mutation approximation for cell population dynamics.
  Sachs RK, Hlatky L. Bull Math Biol. 2010 Feb;72(2):359-74. Epub 2009 Dec 30.  [Abstract | Open Access]
  

[top]

2009

• Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics.
  Enderling H, Beheshti A, Anderson A, Chaplain M, Hlatky L, Hahnfeldt P. Cancer Res. 2009 Nov 15;69(22):8814-21. Epub 2009 Nov 3.  [Abstract | Open Access]
  
  
• An hypothesis: Are pyknons the coding units of the Master Development Program?
  Parris GE. Biosci Hypotheses. 2009;2(5):355.  [Abstract]
  
  
• Stochastic population dynamic effects for lung cancer progression.
  Fakir H, Tan W, Hlatky L, Hahnfeldt P, Sachs RK. Radiat Res. 2009 Sep;172(3):383-93.  [Abstract]
  
  
• Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins.
  Lee TY, Muschal S, Pravda EA, Folkman J, Abdollahi A, Javaherian K. Blood. 2009 Aug 27;114(9):1987-98. Epub 2009 May 22. PMCID: PMC2738581  [Abstract | Open Access]
  
  
• Reply: Inflammatory breast carcinoma as a model of accelerated self-metastatic expansion by intra-vascular growth.
  Enderling H, Hlatky L, Hahnfeldt P. Br J Cancer. 2009;101:1030. Epub 2009 Aug 25.  [Open Access]
  
  
• A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach.
  Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. Radiat Environ Biophys. 2009 Aug;48(3):263-74. Epub 2009 Jun 18. Erratum in: Radiat Environ Biophys. 2011 Nov;50(4):607-8. PMCID: PMC2714893  [Abstract | Open Access]
  
  
• A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation.
  Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. Radiat Environ Biophys. 2009 Aug;48(3):275-86. Epub 2009 Jun 5. Erratum in: Radiat Environ Biophys. 2011 Nov;50(4):607-8. PMCID: PMC2714894  [Abstract | Open Access]
  
  
• Migration rules: tumours are conglomerates of self-metastases.
  Enderling H, Hlatky L, Hahnfeldt P. Br J Cancer. 2009 Jun 16;100(12):1917-25. Epub 2009 May 19. PMCID: PMC2714240  [Abstract | Open Access]
  
  
• Immunosuppressive therapy and post-transplant malignancy.
  Domhan S, Zeier M, Abdollahi A. Nephrol Dial Transplant. 2009 Apr;24(4):1097-103. Epub 2008 Oct 31.  [Abstract | Open Access]
  
  
• Platelets actively sequester angiogenesis regulators.
  Klement GL, Yip TT, Cassiola F, Kikuchi L, Cervi D, Podust V, Italiano JE, Wheatley E, Abou-Slaybi A, Bender E, Almog N, Kieran MW, Folkman J. Blood. 2009 Mar 19;113(12):2835-42. Epub 2008 Nov 25. PMCID: PMC2661866  [Abstract | Open Access]
  
  
• Triggering-response model for radiation-induced bystander effects.
  Fakir H, Hofmann W, Tan WY, Sachs RK. Radiat Res. 2009 Mar;171(3):320-31.  [Abstract]
  
  
• Regarding the most recent common ancestor of HIV-1 Group M.
  Parris GE. Med Hypotheses. 2009 Mar;72(3):360. Epub 2008 Dec 16.  [Abstract]
  
  
• Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype.
  Almog N, Ma L, Raychowdhury R, Schwager C, Erber R, Short S, Hlatky L, Vajkoczy P, Huber PE, Folkman J, Abdollahi A. Cancer Res. 2009 Feb 1;69(3):836-44. Epub 2009 Jan 27.  [Abstract | Open Access]   COVER ARTICLE
  
  
• Cell-cell fusion and cancer: germ-cell cancer and teratomas.
  Parris GE. Med Hypotheses. 2009 Feb;72(2):226. Epub 2008 Dec 11.  [Abstract]
  
  
• Cancer-causing karyotypes: chromosomal equilibria between destabilizing aneuploidy and stabilizing selection for oncogenic function.
  Li L, McCormack AA, Nicholson JM, Fabarius A, Hehlmann R, Sachs RK, Duesberg PH. Cancer Genet Cytogenet. 2009 Jan 1;188(1):1-25.  [Abstract]
  
  
• The importance of spatial distribution of stemness and proliferation state in determining tumor radioresponse.
  Enderling H, Park D, Hlatky L, Hahnfeldt P. Math Model Nat Phenom. 2009 Jan;4(03):117-33.  [Abstract]
  

[top]

2008

• Dependence of invadopodia function on collagen fiber spacing and cross-linking: computational modeling and experimental evidence.
  Enderling H, Alexander NR, Clark ES, Branch KM, Estrada L, Crooke C, Jourquin J, Lobdell N, Zaman MH, Guelcher SA, Anderson AR, Weaver AM. Biophys J. 2008 Sep;95(5):2203-18. Epub 2008 May 30. PMCID: PMC2517013  [Abstract | Open Access]
  
  
• Mathematical Modelling of Breast Carcinogenesis, Treatment with Surgery and Radiotherapy and Local Recurrence.
  Enderling H, Vaidya JS. In: Bellomo N, Chaplain MAJ, De Angelis E (eds). Selected Topics in Cancer Modeling. Genesis, Evolution, Immune Competition, and Therapy. Birkhäuser Boston, 2008:337-362. In Series: Modeling and Simulation in Science, Engineering and Technology: Bellomo N (series ed).  [Chapter]
  
  
• Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid.
  Domhan S, Muschal S, Schwager C, Morath C, Wirkner U, Ansorge W, Maercker C, Zeier M, Huber PE, Abdollahi A. Mol Cancer Ther. 2008 Jun;7(6):1656-68.  [Abstract | Open Access]
  
  
• Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy.
  Timke C, Zieher H, Roth A, Hauser K, Lipson KE, Weber KJ, Debus J, Abdollahi A, Huber PE. Clin Cancer Res. 2008 Apr 1;14(7):2210-9.  [Abstract | Open Access]
  
  
• SU11657 enhances radiosensitivity of human meningioma cells.
  Milker-Zabel S, Zabel-du Bois A, Ranai G, Trinh T, Unterberg A, Debus J, Lipson KE, Abdollahi A, Huber PE. Int J Radiat Oncol Biol Phys. 2008 Mar 15;70(4):1213-8. Epub 2008 Jan 30.  [Abstract]
  
  
• Platelet-associated PF-4 as a biomarker of early tumor growth.
  Cervi D, Yip TT, Bhattacharya N, Podust VN, Peterson J, Abou-Slaybi A, Naumov GN, Bender E, Almog N, Italiano JE Jr, Folkman J, Klement GL. Blood. 2008 Feb 1;111(3):1201-7. Epub 2007 Oct 3.  [Abstract | Open Access]
  
  
• Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released.
  Italiano JE Jr, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, Klement GL. Blood. 2008 Feb 1;111(3):1227-33. Epub 2007 Oct 25. PMCID: PMC2214735  [Abstract | Open Access]
  
  
• Systems biology and its potential role in radiobiology.
  Feinendegen L, Hahnfeldt P, Schadt EE, Stumpf M, Voit EO. Radiat Environ Biophys. 2008 Feb;47(1):5-23. Epub 2007 Dec 18.  [Abstract]
  
  
• Anti-fusion drug candidates that may have beneficial effects against cancer, virus infections and autoimmune disorders.
  Parris GE. Med Hypotheses. 2008;70(2):463. Epub 2007 Jul 25.  [Abstract]
  
  
• Mathematical modeling of stem cells related to cancer.
  Piotrowska MJ, Enderling H, an der Heiden U, Mackey MC. In: Dittmar T, Zänker KS (eds). Cancer and Stem Cells. Nova Science Publishers, Inc., 2008:11-36.
  

[top]

2007

• Second cancers after fractionated radiotherapy: stochastic population dynamics effects.
  Sachs RK, Shuryak I, Brenner D, Fakir H, Hlatky L, Hahnfeldt P. J Theor Biol. 2007 Dec 7;249(3):518-31. Epub 2007 Aug 12. PMCID: PMC2169295  [Abstract]
  
  
• Individualized estimates of second cancer risks after contemporary radiation therapy for Hodgkin lymphoma.
  Hodgson DC, Koh ES, Tran TH, Heydarian M, Tsang R, Pintilie M, Xu T, Huang L, Sachs RK, Brenner DJ. Cancer. 2007 Dec 1;110(11):2576-86.  [Abstract | Open Access]
  
  
• Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues.
  Shuryak I, Sachs RK, Brenner DJ. Radiat Res. 2007 Dec;168(6):741-9. Erratum in: Radiat Res 2008 Apr;169(4):481.  [Abstract]
  
  
• Reducing second breast cancers: a potential role for prophylactic mammary irradiation.
  Brenner DJ, Shuryak I, Russo S, Sachs RK. J Clin Oncol. 2007 Nov 1;25(31):4868-72.  [Abstract | Open Access]
  
  
• Anti-inflammatory effects of alphav integrin antagonism in acute kidney allograft rejection.
  Bedke J, Kiss E, Behnes CL, Popovic ZV, Heuser M, Stojanovic T, Sijmonsma T, Huber P, Domhan S, Muschal S, Abdollahi A, Gretz N, Gröne HJ. Am J Pathol. 2007 Oct;171(4):1127-39. Epub 2007 Aug 16. PMCID: PMC1988864  [Abstract | Open Access]
  
  
• Transcriptional network governing the angiogenic switch in human pancreatic cancer.
  Abdollahi A, Schwager C, Kleeff J, Esposito I, Domhan S, Peschke P, Hauser K, Hahnfeldt P, Hlatky L, Debus J, Peters JM, Friess H, Folkman J, Huber PE. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12890-5. Epub 2007 Jul 24. PMCID: PMC1931565  [Abstract | Open Access]
  
  
• Subtraction of background damage in PFGE experiments on DNA fragment-size distributions.
  Ponomarev AL, Belli M, Hahnfeldt PJ, Hlatky L, Sachs RK, Cucinotta FA. Radiat Environ Biophys. 2007 Jun;46(2):155-60. Epub 2007 Apr 4.  [Abstract]
  
  
• Interpreting chromosome aberration spectra.
  Levy D, Reeder C, Loucas B, Hlatky L, Chen A, Cornforth M, Sachs R. J Comput Biol. 2007 Mar;14(2):144-55.  [Abstract]
  

[top]

2006

• Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks.
  Shuryak I, Sachs RK, Hlatky L, Little MP, Hahnfeldt P, Brenner DJ. J Natl Cancer Inst. 2006 Dec 20;98(24):1794-806.  [Abstract | Open Access]
  
  
• A robust procedure for removing background damage in assays of radiation-induced DNA fragment distributions.
  Ponomarev AL, Belli M, Hahnfeldt PJ, Hlatky L, Sachs RK, Cucinotta FA. Radiat Res. 2006 Dec;166(6):908-16.  [Abstract]
  

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