Shiva Kalinga, PhD
Assistant Investigator
Center of Cancer Systems Biology
St. Elizabeth's Medical Center
Tufts University School of Medicine
736 Cambridge Street, CBR 119
Boston, MA 02135
Tel: 617.779.6536
Fax: 617.779.6572
Mail: shiva.kalinga [at] steward.org
Education and Training:
Postdoctoral fellowship, Bioengineering, MIT
Ph.D., Biochemistry, ETHZ, Switzerland
M.S., Microbiology, BU, India
Research Support:
- MIT-Merck Postdoctoral Training Grant, USA (2005–07): Genomic Approaches to Understanding Cellular Determinants of DNA Damage
- Swiss National Foundation for Scientific Research Scholarship, Switzerland (2000–2005): Post-translation Modifications of Hemeproteins
- Global COE Summer Research Grant, Japan (2004): Design and Construction of Artificial Functional Myoglobin
Selected Publications:
- Herold S, Kalinga S, Matsui T, Watanabe Y. Mechanistic
studies of the Isomerization of Peroxynitrite to Nitrate Catalyzed
by Distal Histidine Metmyoglobin Mutants. J Am Chem Soc 2004; 126:
6945.
- Herold S, Kalinga S. Hemoglobin and Methemoglobin
catalyze the Isomerization of Peroxynitrite to Nitrate. Biochemistry
2003; 42: 14036.
- Herold S, Kalinga S, Mehl M. Myoglobin Scavenges
Peroxynitrite without being Significantly Nitrated. Biochemistry
2002; 41: 13460.
- Kalinga S, Subbayya IN, Balaram H. Development of a
Bacterial Screen for Novel Hypoxanthine-guanine
phosphoribosyltransferase Substrates. J Mol Microbiol Biotechnol
2001; 3: 557.
- Subbayya IN, Sukumaran S, Kalinga S, Balaram H. Unusual
Substrate Specificity of a Chimeric Hypoxanthine-guanine
phosphoribosyltransferase Containing Segments from the Plasmodium
falciparum and Human Enzymes. Biochem Biophys Res Comm 2000; 272:
596.
Book Chapters / Invited Reviews:
- Dedon PC, Barth M, Chen B, DeMott M, Dendroulakis V, Dong M,
Kalinga S, Elmquist E, Margolin Y, Pang B, Zhou X. Diverse
Mechanisms of Endogenous Nucleobase Deamination in DNA and
RNA. Advances in Molecular Toxicology 2006 ed J Fishbein, Elsevier;
Amsterdam pp 25.
- Kalinga S. Interaction of Peroxynitrite with Myoglobin
and Hemoglobin. Can J Chem 2006; 84: 788.