Lynn Hlatky, PhD

Director
Center of Cancer Systems Biology, GRI
Tufts University School of Medicine

Mailing Address:
Center of Cancer Systems Biology
Steward St. Elizabeth's Medical Center
736 Cambridge Street
Boston, MA 02135   USA
 
Tel: 617.789.2997
Mail: lynn.hlatky [at] tufts.edu
 

Lynn Hlatky is the founding director of the Center of Cancer Systems Biology at GRI / Tufts University School of Medicine. Prior to founding the Center, she was at Dana-Farber Cancer Institute and in the Department of Radiation Oncology at Harvard Medical School. The mission of the Center of Cancer Systems Biology (CCSB) is based on the appreciation that carcinogenesis evolves at multiple levels ranging from molecular signalings to cellular and tissue interactions, and that only by their concerted study can the entire process be understood and translated into advances in clinical treatment and the development of novel therapies. Accordingly, the CCSB incorporates researchers with expertise in clinical oncology, cancer biology, molecular biology, radiobiology, bioengineering, mathematics, physics and engineering, chemistry, and computational biology.

Dr. Hlatky also directs three major federal program grants from different national agencies:

• From the National Cancer Institute (NCI), Dr. Hlatky is the principal investigator of one of twelve inter-disciplinary Centers for Cancer Systems Biology under the NCI's Integrative Cancer Biology Program. This collaborative network focuses on the analysis of cancer as a complex biological system. Under this program, our efforts augment the current understanding of carcinogenesis and identify how the tumor cell's environment affects disease development and progression. This work involves collaboration with researchers at NYU Langone Medical Center; at the University of California, Berkeley; and at Lawrence Berkeley National Laboratory.
   
  
• As a designated NASA Specialized Center of Research (NSCOR), our CCSB contributes investigations into radiation-induced carcinogenesis to the multi-institutional mission. Our program involves investigators at University of California, Berkeley and at University of Heidelberg, Germany.
   
  
• Through the Low-Dose Radiation Research Program of the U.S. Department of Energy (DOE), the CCSB investigates the relationship between biological responses to low-dose radiation and health consequences.

In addition, CCSB investigators are collaborating with Dr. Ingolf Tuerk on a translational prostate cancer study, the goal of which is to improve understanding of the characteristics that distinguish different stages of prostate cancer and associated patient prognosis.
 

Research Interests:

• Carcinogenesis and tumor growth dynamics
• Radiobiology
• Translational studies on microenvironmental influence
• DNA damage and repair
• Tumor angiogenesis
• Tumor–cell fusion

Recent Publications:

• Enderling H, Hlatky L, Hahnfeldt P. Cancer stem cells: a minor cancer subpopulation that redefines global cancer features. Front Oncol 3:76, 2013. Epub 2013 Apr 15.
  
  
• Hahnfeldt P, Hlatky L, Klement GL. Center of Cancer Systems Biology Second Annual Workshop — Tumor Metronomics: Timing and Dose Level Dynamics. Cancer Res. 2013 Mar 14. [Epub ahead of print]
  
  
• Girdhani S, Sachs R, Hlatky L. Biological effects of proton radiation: what we know and don't know. Radiat Res 179(3):257-72, 2013. Epub 2013 Feb 1.
  
  
• Gao X, McDonald JT, Hlatky L, Enderling H. Acute and fractionated irradiation differentially modulate glioma stem cell division kinetics. Cancer Res 73(5):1481-90, 2013. Epub 2012 Dec 26.
  
  
• Beheshti A, Sachs RK, Peluso M, Rietman E, Hahnfeldt P, Hlatky L. Age and space irradiation modulate tumor progression: implications for carcinogenesis risk. Radiat Res 179(2):208-20, 2013. Epub 2013 Jan 4.
  
  
• Rietman EA, McDonald JT, Hlatky L. Organism mutation stability and cancer. In: Shoja MM, Agutter PS, Tubbs RS, Ghanei M, Ghabili K, Harris A, Loukas M (eds). Hypotheses in Clinical Medicine. Nova Science Publishers, Inc.; 2013. 594 p.
  
  
• Enderling H, Almog N, Hlatky L, editors. Systems Biology of Tumor Dormancy. New York: Springer; c2013. 291p.
  
  
• Gao X, McDonald JT, Hlatky L, Enderling H. Cell-Cell Interactions in Solid Tumors — the Role of Cancer Stem Cells. In: D'Onofrio A, Cerrai P, Gandolfi A (eds). New Challenges for Cancer Systems Biomedicine. Italy: Springer; c2012. XII, 398p.
  
  
• Sasi SP, Yan X, Enderling H, Park D, Gilbert HY, Curry C, Coleman C, Hlatky L, Qin G, Kishore R, Goukassian DA. Breaking the ‘harmony’ of TNF-α signaling for cancer treatment. Oncogene 31(37):4117-27, 2012. Epub 2011 Dec 12.
   
  
• Satchi-Fainaro R, Ferber S, Segal E, Ma L, Dixit N, Ijaz A, Hlatky L, Abdollahi A, Almog N. Prospective identification of glioblastoma cells generating dormant tumors. PLoS One 7(9):e44395, 2012. Epub 2012 Sep 6.
   
  
• Almog N, Ma L, Schwager C, Brinkmann BG, Beheshti A, Vajkoczy P, Folkman J, Hlatky L, Abdollahi A. Consensus Micro RNAs Governing the Switch of Dormant Tumors to the Fast-Growing Angiogenic Phenotype. PLoS One 7(8):e44001, 2012. Epub 2012 Aug 31.
   
  
• Palladino M, Gatto I, Neri V, Stigliano E, Smith RC, Pola E, Straino S, Gaetani E, Capogrossi M, Leone G, Hlatky L, Pola R. Combined therapy with sonic hedgehog gene transfer and bone marrow-derived endothelial progenitor cells enhances angiogenesis and myogenesis in the ischemic skeletal muscle. J Vasc Res 49(5):425-31, 2012. Epub 2012 Jun 22.
   
  
• Enderling H, Hlatky L, Hahnfeldt P. Immunoediting: Evidence of the multifaceted role of the immune system in self-metastatic tumor growth. Theor Biol Med Model 9(1):31, 2012. Epub 2012 Jul 28.
   
  
• Girdhani S, Lamont C, Hahnfeldt P, Abdollahi A, Hlatky L. Proton irradiation suppresses angiogenic genes and impairs cell invasion and tumor growth. Radiat Res 178(1):33-45, 2012. Epub 2012 Jun 14.
   
  
• Breitkreutz D, Hlatky L, Rietman E, Tuszynski JA. Molecular signaling network complexity is correlated with cancer patient survivability. Proc Natl Acad Sci U S A 109(23):9209-12, 2012. Epub 2012 May 21.
   
  
• Klement GL, Goukassian D, Hlatky L, Carrozza J, Morgan JP, Yan X. Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart. Front Pharmacol 3:113, 2012. Epub 2012 Jun 27.
   
  
• Sharungbam GD, Schwager C, Chiblak S, Brons S, Hlatky L, Haberer T, Debus J, Abdollahi A. Identification of stable endogenous control genes for transcriptional profiling of photon, proton and carbon-ion irradiated cells. Radiat Oncol 7:70, 2012.
   
  
• Radivoyevitch T, Hlatky L, Landaw J, Sachs RK. Quantitative modeling of chronic myeloid leukemia: insights from radiobiology. Blood 119(19):4363-71, 2012. Epub 2012 Feb 21.
   
  
• Enderling H, Hahnfeldt P, Hlatky L, Almog N. Systems biology of tumor dormancy: linking biology and mathematics on multiple scales to improve cancer therapy. Cancer Res 72(9):2172-5, 2012. Epub 2012 Mar 13.
   
  
• Enderling H, Hlatky L, Hahnfeldt P. The promoting role of a tumour-secreted chemorepellent in self-metastatic tumour progression. Math Med Biol 29(1):21-9, 2012. Epub 2010 Oct 5.
   
  
• Hlatky L. Double-strand break motions shift radiation risk notions? Proc Natl Acad Sci U S A 109(2):351-2, 2012. Epub 2011 Dec 30.
   
  
• Morton CI, Hlatky L, Hahnfeldt P, Enderling H. Non-stem cancer cell kinetics modulate solid tumor progression. Theor Biol Med Model 8:48, 2011.
   
  
• Javaherian K, Lee TY, Tjin Tham Sjin RM, Parris GE, Hlatky L. Two Endogenous Antiangiogenic Inhibitors, Endostatin and Angiostatin, Demonstrate Biphasic Cureves in the Antitumor Profiles. Dose Response 9(3):369-76, 2011. Epub 2010 Oct 21.
   
  
• Domhan S, Ma L, Tai A, Anaya Z, Beheshti A, Zeier M, Hlatky L, Abdollahi A. Intercellular communication by exchange of cytoplasmic material via tunneling nano-tube like structures in primary human renal epithelial cells. PLoS One 6(6):e21283, 2011. Epub 2011 Jun 27.
   
  
• Sachs RK, Johnsson K, Hahnfeldt P, Luo J, Chen A, Hlatky L. A multicellular basis for the origination of blast crisis in chronic myeloid leukemia. Cancer Res 71(8):2838-47, 2011. Epub 2011 Apr 12.
   
  
• Barcellos-Hoff MH, Brenner DJ, Brooks LA, Formenti S, Hlatky L, Locke PA, Shore R, Tenforde T, Travis EL, Williams J. Low-dose radition knowledge worth the cost. Science 332(6027):305-6, 2011.
   
  
• McDonald JT, Kim K, Norris AJ, Vlashi E, Phillips TM, Lagadec C, Della Donna L, Ratikan J, Szelag H, Hlatky L, McBride WH. Ionizing radiation activates the Nrf2 antioxidant response. Cancer Res 70(21):8886-95, 2010. Epub 2010 Oct 12.
  
  
• Liangos O, Domhan S, Schwager C, Zeier M, Huber PE, Addabbo F, Goligorsky MS, Hlatky L, Jaber BL, Abdollahi A. Whole blood transcriptomics in cardiac surgery identifies a gene regulatory network connecting ischemia reperfusion with systemic inflammation. PLoS One 5(10):e13658, 2010.
  
  
• Enderling H, Hlatky L, Hahnfeldt P. Tumor morphological evolution: directed migration and gain and loss of the self-metastatic phenotype. Biol Direct 5:23, 2010.
  
  
• Sachs RK, Hlatky L. A rapid-mutation approximation for cell population dynamics. Bull Math Biol 72(2):359-74, 2010.
  
  
• Enderling H, Anderson AR, Chaplain MA, Beheshti A, Hlatky L, Hahnfeldt P. Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics. Cancer Res 69(22):8814-21, 2009. Epub 2009 Nov 3.
  
  
• Fakir H, Tan WY, Hlatky L, Hahnfeldt P, Sachs RK. Stochastic population dynamic effects for lung cancer progression. Radiat Res 172(3):383-93, 2009.
  
  
• Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach. Radiat Environ Biophys 48(3):263-74, 2009. Epub 2009 Jun 18.
  
  
• Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ. A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation. Radiat Environ Biophys 48(3):275-86, 2009. Epub 2009 Jun 5.
  
  
• Enderling H, Hlatky L, Hahnfeldt P. Migration rules: tumours are conglomerates of self-metastases. Br J Cancer 100(12):1917-25, 2009. Epub 2009 May 19.
  
  
• Almog N, Ma L, Raychowdhury R, Schwager C, Erber R, Short S, Hlatky L, Vajkoczy P, Huber PE, Folkman J, Abdollahi A. Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype. Cancer Res 69(3):836-44, 2009. Epub 2009 Jan 27.