CCSB Alumni

 
heiko_enderling
 
Heiko Enderling, PhD. Associate Investigator.
Assistant Professor of Medicine.

Heiko Enderling was a CCSB member from 2006–2013. He joined the CCSB from the University of Dundee, Scotland, where he received his PhD on 'Mathematical Modeling of Breast Cancer Development, Treatment and Recurrence'.
 
Research interests:
  • Basic cancer cell kinetics in tumor dormancy and progression
  • Tumor morphological evolution; self-metastatic phenotype
  • Mathematical modeling of stem cell mutations, tumorigenesis, tumor growth and invasion
  • Irradiation response and radiotherapeutic design
  • Tissue architecture evolution
  • Invadopodia formation and cancer-microenvironment interaction
  • Computational simulations and high-dimensional visualization of mathematical models

 
amir_abdollahi
 
Amir Abdollahi, MD, PhD. Associate Investigator.
Assistant Professor of Medicine.
 
Amir Abdollahi joined the CCSB from the German Cancer Research Center (DKFZ), University of Heidelberg Medical School, where he was head of translational research at the Departments of Radiation Oncology. With Dr. Hlatky, he worked to establish a multidisciplinary research consortium at CCSB bringing together molecular, bioinformatics, and clinical expertise from the DKFZ/Heidelberg University and the Folkman laboratory at Harvard Medical School.
 
Research interests:
  • Systematic transcriptional and functional analysis of cancer with focus on
    • Tumor <=> microenvironment communication
    • Tumor–Angiogenesis (tumor vasculature, i.e., endogenous angiogenesis inhibitors)
    • Tumor–Fibrogenesis (tumor stroma, 'interstitium')
    • Tumor–Metastasis
  • Role of the tumor- microenvironment interplay in acquired resistance to conventional therapies (radiotherapy and chemotherapy) as well as to novel 'targeted' anticancer agents (e.g. antiangiogenic therapy).
  • Preclinical identification of novel therapeutic targets and clinical evaluation of identified targets
  • Identification of potential biomarkers (e.g. gene/protein signatures) of therapeutic response

 
roy_smith
 
Roy Smith, PhD. Assistant Investigator.
 
Roy Smith was a CCSB member from 2009 to 2013. He was previously associated with Tufts University School of Medicine, Boston University School of Medicine, and the Department of Surgical Research at Children's Hospital Boston and Harvard Medical School. He received his PhD in Biological Chemistry from MIT.
 
Research interests:
  • Tumor biology
  • Metastasis
  • Cancer immunology
  • Vascular biology
  • Stress response
  • Sleep apnea
  • Alzheimer's disease

 
george_parris
 
George E. Parris, PhD. Associate Investigator.
Adjunct Research Professor of Medicine.
 
George Parris participated in the CCSB from 2009 through 2012. Most of his career has been as an employee or consultant to the US Environmental Protection Agency, the Food and Drug Administration and the Department of Energy. His work has centered on cancer risk assessment based on environmental exposures to chemicals or radiation. He also holds an adjunct appointment for Johns Hopkins University where he teaches courses in the environmental science and policy curriculum. Over the last few years, he has expanded his activity to a study of cancer from which the risk assessment methodology must follow. He is particularly interested in cell-cell fusion as an important step in the evolution (progression) of cancer. Cell-cell fusion is particularly interesting because it provides a mechanism for rapid (sexual) evolution of cancers, which largely circumvents the need for immortal cells in the cancer (i.e., cancer stem cells). Cell-cell fusion is frequently catalyzed by viruses and other intracellular micro-organisms. Cell-cell fusion also explains the observations that many tumors (neoplasia) are initially diploid, evolve to tetraploid and then become aggressive metastasize concurrent with evolving to aneuploid karyotypes. Many of these features are controlled by cell surface glycoproteins and glycans.
 
Research interests:
  • Cell-cell fusion
  • Cell-virus fusion
  • How cancer cells overcome Muller's ratchet
  • Glycans and glycoproteins
  • Cancer risk assessment
  • Methods of blocking cell fusion

 
kashi_javaherian
 
Kashi Javaherian, PhD. Senior Investigator.

Before joining the CCSB, Kashi Javaherian was associated with the late Dr. Judah Folkman at Children's Hospital Boston for many years. The main focus of Kashi's research centered around two angiogenic inhibitors, angiostatin and endostatin; two proteins first discovered in Folkman's laboratory. He has been the senior author or co-author on a number of major publications dealing with these inhibitors.
 
Research interests:
  • Structure, function and mechanism of angiogenic inhibitors angiostatin and endostatin
  • Developing new antiangiogenic peptides and proteins based on identification of specific proteins responsible for angiogenesis in cancer

 
mahdokht_behravan
 
Mahdokht Behravan, PhD. Research Associate.
 
Mady joined the CCSB from the Medical Imaging Group in the Department of Radiation Oncology at the University of Michigan. She received her PhD in Experimental Condensed Matter Physics from Michigan State University, Department of Physics and Astronomy, in 2005. IAEA Fellowships include the KFKI Atomic Energy Research Institute, Hungarian Academy of Sciences and the International Center for Theoretical Physics, Trieste, Italy.
 
Research interests:
  • Bioelectric signaling and membrane potential
  • Cell interaction and attachment
  • Radiation carcinogenesis
  • Nanotechnology in diagnostics and therapy

 
david_goukassian
 
David A. Goukassian, MD, PhD. Senior Investigator.
Associate Professor of Medicine.
 
David Goukassian joined the CCSB from the Departments of Dermatology and Medicine at Boston University School of Medicine where he was head of the Translational Research Unit. In 2012, David moved to a full-time position in the Center for Cardiovascular Research. During his time with the CCSB, his research work was focused on the development of novel treatment modalities based on inhibition of TNF signaling via selective blocking of its receptors (p55 or p75) for treatment of various human tumors including, but not limited to skin, breast, prostate and lung cancers. His current research interest is focused in the area of space radiobiology, specifically, evaluation of space radiation-induced damage to bone marrow endothelial progenitors cells (EPCs) and resident endothelial cells (ECs) in the myocardium and associated long-term degenerative cardiovascular (CV) risks.
 
Research interests:
  • DNA damage and Repair
  • Aging, tissue repair and regeneration
  • Endothelial and endothelial progenitor cell biology in physiological and pathological angiogenesis
  • Hematopoietic and mesenchymal stem and progenitor cells
  • Tumor angiogenesis, invasion and metastasis
  • Tumor prevention and therapeutics
  • Animal models of human cancers
  • Space radiobiology:
    • Molecular mechanisms of long-term CV degenerative risks
    • Development of mouse models for evaluation of space radiation-induced Excess Relative Risks (ERR)
    • Development of predictive biomarkers for ERR

 
ezra_aurian-blajeni
 
Dan Ezra Aurian-Blajeni. Summer 2012 Volunteer.
 
University of Massachusetts at Amherst, Biochemistry and Molecular Biology major
 
Ezra assisted with imaging projects for Nava Almog and Tyson McDonald, as well as in animal evaluation with Janusz Weremowicz during the Summer of 2012.
 

 
 
Adannia Nwangwu. Summer 2012 Student Volunteer.

During the summer of 2012, as a rising senior at Lynnfield High School, Adannia assisted and learned from several researchers and technicians in the lab.
 

 
cole_steber
 
 
Cole Steber. 2012 NCI ICBP Undergraduate Summer Research Fellow.

Mathematics and Biology major, Centre College, Danville, KY
 
Cole joined the CCSB for the summer of 2012 as a fellow in the NCI's ICBP Summer Cancer Research Fellowship/Internship program. He worked closely with mentors Tyson McDonald and Edward Rietman, conducting research on a project entitled, "Characterizing the regenerative potential of irradiated brain tumor cell populations."
 

 
 
Ashwini Manjunatha. Summer 2012 Student Volunteer.

During her time with the CCSB in the Summer of 2012, Ashwini was a rising junior at Acton-Boxborough Regional High School. She worked with and learned from several researchers and technicians in the lab.
 

 
sophie_domhan
 
Sophie Domhan, MD. Research Associate.
 
Sophie joined the CCSB in 2008 from University of Heidelberg Medical School where she received her MD, and is trained in Internal Medicine (Department of Nephrology).
 
Research interests:
  • Immunosuppressive drugs and cancer
  • Tumor-microenvironment and angiogenesis
  • Epithelial-mesenchymal transition

 
charles_morton
Charles Morton, PhD. Postdoctoral Fellow.

After receiving his PhD in molecular and systems toxicology and pharmacology in the Department of Biological Engineering at MIT, Charles underwent postdoctoral training at the CCSB from 2009 to 2012.
 
Research interests:
  • Agent-based modeling of tumor growth kinetics
  • Dynamics of intercellular communication through exosomal miRNA
  • Theoretical modeling of the tumor-microenvironment milieu

 
david_story David Story, PhD. Assistant Investigator.

David joined the CCSB from Solar Plexus Nexus, a solar energy research start-up, in 2010. His background includes Electrical Engineering design and development and Plasma Physics research associated with microplasma instabilities and thin film deposition. Additionally, David has specialized training and experience in micromachines and nonlinear systems.
 
Research interests:
  • Carcinogenesis and tumor growth dynamics
  • Molecular micromachines and cellular nonlinear systems
  • Self-organizing systems

 
peter_nowd Peter Nowd. Research Technician.

B.S. Biology, Stonehill College
 
• Aprepitant as salvage antiemetic therapy in breast cancer patients receiving doxorubicin and cyclophosphamide; Supportive Care in Cancer, 2009, Volume 17, Number 9, pages 1065-1070.
 

 
julia_fox Julia Fox, PhD. Assistant Investigator.
 
Julia joined the CCSB in 2010 from the Broad Institute and the Harvard Stem Cell Institute and where she was involved in cross-center collaborations focused on the discovery of small molecules and conditions which specifically promote the differentiation of stem cells into desired mature and functional cell types.
 
Research interests:
  • Characterization of cellular networks responsible for tissue maintenance and the "stem cell niche", and how such a program relates to the relationship between tumor maintenance and cancer stem cells
  • Systematic study of signaling networks which govern the development and function of specified tissues
  • Tissue and stage specific regulation of gene expression, genome-wide gene expression analysis, and gene signature development
  • High throughput automated microscopy and image analysis
  • High throughput and high content chemical screening

 
heather_szelag Heather Szelag. Research Technician.
 
B.S. Biophysics/Structural Biology, University of Connecticut
 
Heather worked with the CCSB from 2008 to 2011 as an integral member of the translational research program. She worked closely with Giannoula Klement and Ingolf Tuerk in the establishment and day-to-day operations of our prostate cancer efforts.
 

 
jawon_lee Jawon Lee. 2011 NCI ICBP Undergraduate Summer Research Fellow.
 
B.A. Microbiology and Computer Science, University of California, San Diego
 
Jawon joined the CCSB for the summer of 2011 as a fellow in the NCI's ICBP Summer Cancer Research Fellowship/Internship program. She worked closely with mentors Tyson McDonald and Heiko Enderling on a research project entitled, "Characterizing the regenerative potential of irradiated cancer cell populations." Her research interests include computer modeling and analysis of large biological data sets.
 
  • McDonald JT, Lee L, Rietman E, Lamont C, Peluso M, Enderling H, Hlatky L. Increased cytokine and chemokine expression inU87MG glioblastoma cells after large clinically relevant single doses of ionizing radiation. Poster accepted for presentation at AACR Annual Meeting 2012. April 3, 2012: Chicago, IL.
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    annie_kang Annie Kang. Research Technician.
     
    B.A. Biology, Boston University

     
    glenn_stern Glenn Stern, MBA. Administrative Director of Laboratory Research.
     
    Glenn was the Administrative Director of Laboratory Research for the Center of Cancer Systems Biology from 2009 to 2011.

     
    niharika_dixit Niharika Dixit, MD. Clinical Fellow.
     
    Niharika collaborated with the CCSB on translational research during her Hematology/ Oncology Fellowship at St. Elizabeth's Medical Center.

     
    erik_fung
    Erik Fung, MD, PhD. Clinical Fellow.
     
    Hematology/Oncology Fellow at St. Elizabeth's Medical Center
     

     
    ambreen_ijaz
    Ambreen Ijaz, MD. Clinical Fellow.
     
    Ambreen collaborated with the CCSB on translational research during her Hematology/Oncology Fellowship at St. Elizabeth's Medical Center.

     
      Colleen Yavarow, MD. Clinical Fellow.
     
    Colleen collaborated with the CCSB on translational research during her Hematology/Oncology Fellowship at St. Elizabeth's Medical Center.
     

     
    maria_sousa
    Maria Sousa. Summer student.
     
    Maria worked with Tyson McDonald during the summer of 2010.




     
    sangita_murali
    Sangita Murali. Summer student.
     
    Bates College 2012.
    Major: Neuroscience with a Concentration in Philosophy and Mathematics
     
    Sangita worked with Giannoula Klement and Nava Almog during the summer of 2010.

     
    zachary_anaya Zachary Anaya. Research Technician.
     
    B.Sc. Neuroscience, Dalhousie University

     
    birin_padam Birin Padam. Summer student.
     
    Johns Hopkins University 2014
    Major: Neuroscience
     
    Birin worked with Afshin Beheshti.

     
    joseph_pariseau Joseph Pariseau. Summer student.
     
    Joseph worked with Giannoula Klement during the summer of 2010.


     
    derek_park Derek Park. Summer student.

    Derek worked in our lab as a summer student from Weston High School in 2008 and 2009, where he was involved in different projects with his mentor Heiko Enderling.

    Projects:
    • Statistical analysis of simulation results for tumor radiotherapy
    • Developing an algorithm to calculate the concave hull of a tumor cell cluster

     
    daniel_seth_greenstein Daniel Seth Greenstein. Part-time research technician.

    B.A. Psychology, Middlebury College

     
    terese_dane Therese Dane. Summer student.

    Therese worked with our lab while she was a Biology Major at Rochester Institute of Technology.

     

     
    mia_edgar Mia Edgar. Summer student.

    Mia joined us for a summer while she was studying PreMed at Boston College.

     

     
    blake_wang Blake Wang. Summer student.

    Blake was a summer student from Weston High School.

     
    bianling_liu Bianling Liu, MD. Senior Research Associate.

    Research interests:
    • Understanding cellular and molecular mechanisms underlining stem cell pluripotency, self- renewal, migration and homing and testing the possible stem cell based approaches for tissue repair and regenerative medicine, her study focuses on adult stem cell, especially hematopoietic stem cell (HSC), mesenchymal stem cell (MSC) and endothelial progenitor cells (EPC)

    • Investigating the role of cancer stem cell on tumor initiation, migration and metastasis and developing effective theraputics for cancer cure; identification of CD44 as a biomarker for cancer and cancer stem cell function

     
    zili_tang Zili Tang, MD. PhD Candidate.
     
    M.Sc. Biotechnology, Hochschule Mannheim, Germany
    M.D. Chengdu University of TCM, China
     

     
    olga_kiner Olga Kiner, Research Technician.
     
    M.S. Molecular Biology, Bar-Ilan University, Israel
    B.Sc. Medical Science, Hadassah College, Israel

     
    roslyn_whitley Roslyn Whitley, Research Technician.
     
    Ecology and Evolutionary Biology, Princeton University
    Ruth Grau Zises Women's Health Student Research Award, 2007
    ‘analyzing the effects/side effects of cabergoline on a neuroendocrine abnormality of the pituitary gland that disproportionately affects women’

     
    raktima_raychowdhury
     
    Raktima Raychowdhury, PhD. Senior Research Associate.
     
    Raktima joined CCSB from Massachusetts General Hospital, Harvard Medical School in 2007.
     
    Research interests:
    • Role of radiation and microenvironment in carcinogenesis
    • Molecular biology of cancer

     
    mohsen_hosseinkhani
     
    Mohsen Hosseinkhani, PhD. Research Associate.
     
    Mohsen joined CCSB in 2008.

    Research interests:
    • Characterization of cancer stem cells in different tumors and analysis of their stemness properties
    • Analysis of cancer stem cell differentiation potential
    • Developing specific therapies that target cancer stem cells that improve survival and quality of life of cancer patients, especially for sufferers of metastatic disease

     
    baili_chen
     
    Baili Chen, PhD. Research Associate.
     
    Baili joined CCSB in 2008. She obtained her PhD from Texas Tech University in 2005 for her thesis entitled 'Mathematical Models of Motion Detection in the Fly's Visual Cortex'.

    Research interests:
    • Mathematical modeling of multi-stage carcinogenesis
    • Mathematical modeling of tumor microenvironment and angiogenesis

     
    jaclyn_nestor Jaclyn Nestor, Research Technician.

     
    armine_matevossian Armine Matevossian, Research Technician.

     
    aaron_burg Aaron Burg, Research Technician.
     

     
     

     

     
    matthew_perkins Matthew Perkins, Research Technician.
     

     
     

     

     

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